Methyl (2S)-2-(benzoyloxy)-5-hydroxypentanoate

Base Information

Chemical Name:Methyl (2S)-2-(benzoyloxy)-5-hydroxypentanoate
CAS No.:156693-54-8
Molecular Formula:C₁₃H₁₆O₅
Molecular Weight:252.267
Hs Code.:

Synonyms:

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Chemical Property of Methyl (2S)-2-(benzoyloxy)-5-hydroxypentanoate

Chemical Property:

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Technology Process of Methyl (2S)-2-(benzoyloxy)-5-hydroxypentanoate

There total 6 articles about Methyl (2S)-2-(benzoyloxy)-5-hydroxypentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
L-glutamic acid

: 156693-54-8
Methyl (2S)-2-(benzoyloxy)-5-hydroxypentanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 50 percent / conc. H₂SO₄ / diethyl ether

2: 68 percent / aq. TFA, NaNO₂ / 2 h / Ambient temperature

3: NaHCO₃ / dimethylformamide / 48 h / Ambient temperature

4: 80 percent / 4-(dimethylamino)pyridine, pyridine / 1.) 0 deg C, 1 h, 2.) room temp., 24 h

5: H₂ / 10percent Pd-C / methanol / 30 °C / 2585.7 Torr

6: BH₃*THF / tetrahydrofuran / Ambient temperature

With pyridine; dmap; borane-THF; sulfuric acid; hydrogen; sodium hydrogencarbonate; trifluoroacetic acid; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jo00093a008

Reference yield:

: 1676-73-9,25014-27-1
L-glutamic acid γ-benzyl ester

: 156693-54-8
Methyl (2S)-2-(benzoyloxy)-5-hydroxypentanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 68 percent / aq. TFA, NaNO₂ / 2 h / Ambient temperature

2: NaHCO₃ / dimethylformamide / 48 h / Ambient temperature

3: 80 percent / 4-(dimethylamino)pyridine, pyridine / 1.) 0 deg C, 1 h, 2.) room temp., 24 h

4: H₂ / 10percent Pd-C / methanol / 30 °C / 2585.7 Torr

5: BH₃*THF / tetrahydrofuran / Ambient temperature

With pyridine; dmap; borane-THF; hydrogen; sodium hydrogencarbonate; trifluoroacetic acid; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00093a008

Reference yield:

: 156693-50-4
5-benzyloxycarbonyl-2-hydroxy-pentanedioic acid

: 156693-54-8
Methyl (2S)-2-(benzoyloxy)-5-hydroxypentanoate

Guidance literature:: Multi-step reaction with 4 steps

1: NaHCO₃ / dimethylformamide / 48 h / Ambient temperature

2: 80 percent / 4-(dimethylamino)pyridine, pyridine / 1.) 0 deg C, 1 h, 2.) room temp., 24 h

3: H₂ / 10percent Pd-C / methanol / 30 °C / 2585.7 Torr

4: BH₃*THF / tetrahydrofuran / Ambient temperature

With pyridine; dmap; borane-THF; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00093a008