Hexanoic acid, 6-hydroxy-, phenylmethyl ester

Base Information

• Chemical Name: Hexanoic acid, 6-hydroxy-, phenylmethyl ester
• CAS No.: 125878-06-0
• Molecular Formula: C13H18O3
• Molecular Weight: 222.284
• Mol file: 125878-06-0.mol

Synonyms:

Chemical Property of Hexanoic acid, 6-hydroxy-, phenylmethyl ester

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Hexanoic acid, 6-hydroxy-, phenylmethyl ester

There total 19 articles about Hexanoic acid, 6-hydroxy-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

6-(tert-butyldimethyl)siloxyhexanoic benzyl ester (125878-05-9) → 6-hydroxyhexanoic acid phenylmethyl ester (125878-06-0)

Guidance literature:

With pyridine; hydrogen fluoride; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1021/ja00164a026

Reference yield: 89.0%

hexahydro-2H-oxepin-2-one (502-44-3,24980-41-4,80137-66-2) + benzyl chloride (100-44-7) → 6-hydroxyhexanoic acid phenylmethyl ester (125878-06-0)

Guidance literature:

hexahydro-2H-oxepin-2-one; With tetra(n-butyl)ammonium hydroxide; at 65 ℃; for 2h;

benzyl chloride; In N,N-dimethyl-formamide; for 24h;

DOI:10.1139/v00-068

Reference yield: 85.0%

6-Hydroxyhexanoic acid (1191-25-9) + benzyl bromide (100-39-0) → 6-hydroxyhexanoic acid phenylmethyl ester (125878-06-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.jorganchem.2012.06.001

upstream raw materials:

6-(tert-butyldimethyl)siloxyhexanoic benzyl ester

hexahydro-2H-oxepin-2-one

benzyl chloride

benzyl alcohol

Downstream raw materials:

6-(tert-butyldimethyl)siloxyhexanoic benzyl ester

benzyl 6-(4-chlorobutanoyloxy)hexanoate

6-(benzyloxy)-6-oxohexyl 3,4-di-O-benzyl-6-deoxy-β-L-mannopyranoside

6-methoxy-6-oxohexyl 3,4-di-O-benzyl-2-O-(2,4-di-O-benzyl-6-deoxy-α-L-mannopyranosyl)-6-deoxy-β-L-mannopyranoside