N-[4-(3,5-dioxo-hexyl)-phenyl]-3-{2-[2-(2-{2-[4-({[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-methyl-carbamoyl}-methyl)-phenoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionamide

Base Information

• Chemical Name: N-[4-(3,5-dioxo-hexyl)-phenyl]-3-{2-[2-(2-{2-[4-({[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-methyl-carbamoyl}-methyl)-phenoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionamide
• CAS No.: 929088-02-8
• Molecular Formula: C₅₁H₅₇N₅O₁₃S
• Molecular Weight: 980.105

Synonyms:

Chemical Property of N-[4-(3,5-dioxo-hexyl)-phenyl]-3-{2-[2-(2-{2-[4-({[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-methyl-carbamoyl}-methyl)-phenoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[4-(3,5-dioxo-hexyl)-phenyl]-3-{2-[2-(2-{2-[4-({[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-methyl-carbamoyl}-methyl)-phenoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionamide

There total 11 articles about N-[4-(3,5-dioxo-hexyl)-phenyl]-3-{2-[2-(2-{2-[4-({[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-methyl-carbamoyl}-methyl)-phenoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(4-nitrophenyl)hexane-2,4-dione (192650-25-2) → N-[4-(3,5-dioxo-hexyl)-phenyl]-3-{2-[2-(2-{2-[4-({[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-methyl-carbamoyl}-methyl)-phenoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionamide (929088-02-8)

Guidance literature:

Multi-step reaction with 8 steps

1: 65 percent / pTSA / toluene / Heating

2: 95 percent / H₂ / Pd/C / ethyl acetate

3: EDCI / CH₂Cl₂ / 0 °C

4: piperidine / CH₂Cl₂ / 20 °C

5: CH₂Cl₂ / 20 °C

6: LiOH / tetrahydrofuran; H₂O

7: EDCI / CH₂Cl₂

8: pTSA; water / acetone

With piperidine; lithium hydroxide; water; hydrogen; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; ethyl acetate; acetone; toluene;

DOI:10.1016/j.bmcl.2006.10.009

Reference yield:

C16H21NO6 (782475-33-6) → N-[4-(3,5-dioxo-hexyl)-phenyl]-3-{2-[2-(2-{2-[4-({[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-methyl-carbamoyl}-methyl)-phenoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionamide (929088-02-8)

Guidance literature:

Multi-step reaction with 7 steps

1: 95 percent / H₂ / Pd/C / ethyl acetate

2: EDCI / CH₂Cl₂ / 0 °C

3: piperidine / CH₂Cl₂ / 20 °C

4: CH₂Cl₂ / 20 °C

5: LiOH / tetrahydrofuran; H₂O

6: EDCI / CH₂Cl₂

7: pTSA; water / acetone

With piperidine; lithium hydroxide; water; hydrogen; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; ethyl acetate; acetone;

DOI:10.1016/j.bmcl.2006.10.009

Reference yield:

acetylacetone (123-54-6,81235-32-7) → N-[4-(3,5-dioxo-hexyl)-phenyl]-3-{2-[2-(2-{2-[4-({[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-methyl-carbamoyl}-methyl)-phenoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionamide (929088-02-8)

Guidance literature:

Multi-step reaction with 9 steps

1: 40 percent / LDA / hexamethylphosphoric acid triamide / -78 °C

2: 65 percent / pTSA / toluene / Heating

3: 95 percent / H₂ / Pd/C / ethyl acetate

4: EDCI / CH₂Cl₂ / 0 °C

5: piperidine / CH₂Cl₂ / 20 °C

6: CH₂Cl₂ / 20 °C

7: LiOH / tetrahydrofuran; H₂O

8: EDCI / CH₂Cl₂

9: pTSA; water / acetone

With piperidine; lithium hydroxide; water; hydrogen; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; water; ethyl acetate; acetone; toluene;

DOI:10.1016/j.bmcl.2006.10.009

upstream raw materials:

6-(4-nitrophenyl)hexane-2,4-dione

4-{2-[2-(2-Methyl-[1,3]dioxolan-2-ylmethyl)-[1,3]dioxolan-2-yl]-ethyl}-phenylamine

C₁₆H₂₁NO₆

(4-{2-[2-(2-{2-[2-(4-{2-[2-(2-methyl-[1,3]dioxolan-2-ylmethyl)-[1,3]dioxolan-2-yl]-ethyl}-phenylcarbamoyl)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-phenyl)-acetic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 929088-02-8 N-[4-(3,5-dioxo-hexyl)-phenyl]-3-{2-[2-(2-{2-[4-({[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-methyl-carbamoyl}-methyl)-phenoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send