2-Propenoic acid, 3-(4-methylphenyl)-, 1,1-dimethylethyl ester, (2E)-

Base Information

• Chemical Name: 2-Propenoic acid, 3-(4-methylphenyl)-, 1,1-dimethylethyl ester, (2E)-
• CAS No.: 125951-00-0
• Molecular Formula: C₁₄H₁₈O₂
• Molecular Weight: 218.296
• Mol file: 125951-00-0.mol

Synonyms:

Chemical Property of 2-Propenoic acid, 3-(4-methylphenyl)-, 1,1-dimethylethyl ester, (2E)-

Chemical Property:

Purity/Quality:

99.0%min. ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenoic acid, 3-(4-methylphenyl)-, 1,1-dimethylethyl ester, (2E)-

There total 21 articles about 2-Propenoic acid, 3-(4-methylphenyl)-, 1,1-dimethylethyl ester, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-Butyl acrylate (1663-39-4,25232-27-3) + 4-tolyl iodide (624-31-7) → tert-butyl 4-methylcinnamate (136053-53-7,125951-00-0)

Guidance literature:

With tetrabutyl ammonium fluoride; palladium dichloride; at 40 ℃; for 3h; Inert atmosphere; neat (no solvent);

DOI:10.3184/030823410X12706650130972

Reference yield: 99.0%

tert-Butyl acrylate (1663-39-4,25232-27-3) + 4-methylbenzenediazonium tetrafluoroborate (459-44-9) → tert-butyl 4-methylcinnamate (136053-53-7,125951-00-0)

Guidance literature:

With 1,6,11-triazacyclopentadeca-3,8,12-triene Pd; In ethanol; at 20 ℃; for 3h;

DOI:10.1021/ol034340b

Reference yield: 98.0%

bromoacetic acid tert-butyl ester (5292-43-3) + 4-methyl-benzaldehyde (104-87-0) → tert-butyl 4-methylcinnamate (136053-53-7,125951-00-0)

Guidance literature:

bromoacetic acid tert-butyl ester; With triphenylphosphine; In toluene; at 20 ℃; for 24h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

4-methyl-benzaldehyde; In tetrahydrofuran; at 60 ℃; for 20h;

DOI:10.1016/j.ejmech.2020.112411

upstream raw materials:

tert-butyl bis(trimethylsilyl)acetate

4-methyl-benzaldehyde

tert-Butyl acrylate

4-tolyl iodide