(2S,4R)-2-((1R,2R)-2-But-3-enyl-1-tert-butoxycarbonyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(2S,4R)-2-((1R,2R)-2-But-3-enyl-1-tert-butoxycarbonyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:770742-59-1
Molecular Formula:C₃₈H₄₇N₃O₇
Molecular Weight:657.807
Hs Code.:

(2S,4R)-2-((1R,2R)-2-But-3-enyl-1-tert-butoxycarbonyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (2S,4R)-2-((1R,2R)-2-But-3-enyl-1-tert-butoxycarbonyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of (2S,4R)-2-((1R,2R)-2-But-3-enyl-1-tert-butoxycarbonyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 11 articles about (2S,4R)-2-((1R,2R)-2-But-3-enyl-1-tert-butoxycarbonyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1S,2S)-2-But-3-enyl-1-(2-trimethylsilanyl-ethoxycarbonylamino)-cyclopropanecarboxylic acid tert-butyl ester

: 259214-37-4
(2S,4R)-1-(tert-butoxycarbonyl)-4-(7-methoxy-2-phenylquinolin-4-yloxy)pyrrolidine-2-carboxylic acid

: (2S,4R)-2-((1S,2S)-2-But-3-enyl-1-tert-butoxycarbonyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 770742-59-1
(2S,4R)-2-((1R,2R)-2-But-3-enyl-1-tert-butoxycarbonyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: (1S,2S)-2-But-3-enyl-1-(2-trimethylsilanyl-ethoxycarbonylamino)-cyclopropanecarboxylic acid tert-butyl ester; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

(2S,4R)-1-(tert-butoxycarbonyl)-4-(7-methoxy-2-phenylquinolin-4-yloxy)pyrrolidine-2-carboxylic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃;
DOI:10.1021/jo049288r

Reference yield:

: 94-02-0
ethyl 3-oxo-3-phenylpropionate

: 770742-59-1
(2S,4R)-2-((1R,2R)-2-But-3-enyl-1-tert-butoxycarbonyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: HCl / dioxane; toluene

2.1: 44 percent / Pyrolysis

3.1: Ph₃P; diisopropyl azodicarboxylate / tetrahydrofuran / 15 h / 20 °C

4.1: LiOH; water / tetrahydrofuran; methanol / 16 h / 20 °C

5.1: TBAF / tetrahydrofuran / 20 °C

5.2: HATU; DIPEA / CH₂Cl₂ / 20 °C

With hydrogenchloride; lithium hydroxide; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; water; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; toluene; 3.1: Mitsunobu reaction;
DOI:10.1021/jo049288r

Reference yield:

: 536-90-3,918666-97-4
m-Anisidine

: 770742-59-1
(2S,4R)-2-((1R,2R)-2-But-3-enyl-1-tert-butoxycarbonyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: HCl / dioxane; toluene

2.1: 44 percent / Pyrolysis

3.1: Ph₃P; diisopropyl azodicarboxylate / tetrahydrofuran / 15 h / 20 °C

4.1: LiOH; water / tetrahydrofuran; methanol / 16 h / 20 °C

5.1: TBAF / tetrahydrofuran / 20 °C

5.2: HATU; DIPEA / CH₂Cl₂ / 20 °C

With hydrogenchloride; lithium hydroxide; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; water; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; toluene; 3.1: Mitsunobu reaction;
DOI:10.1021/jo049288r