4-(2-chlorophenyl)-5-(2-cyanoethoxycarbonyl)-3-ethoxycarbonyl-6-methyl-2-(2-phtalimidoethoxymethyl)-1,4-dihydropyridine

Base Information

• Chemical Name: 4-(2-chlorophenyl)-5-(2-cyanoethoxycarbonyl)-3-ethoxycarbonyl-6-methyl-2-(2-phtalimidoethoxymethyl)-1,4-dihydropyridine
• CAS No.: 120300-92-7
• Molecular Formula: C₃₀H₂₈ClN₃O₇
• Molecular Weight: 578.021
• Mol file: 120300-92-7.mol

Synonyms:

Chemical Property of 4-(2-chlorophenyl)-5-(2-cyanoethoxycarbonyl)-3-ethoxycarbonyl-6-methyl-2-(2-phtalimidoethoxymethyl)-1,4-dihydropyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-chlorophenyl)-5-(2-cyanoethoxycarbonyl)-3-ethoxycarbonyl-6-methyl-2-(2-phtalimidoethoxymethyl)-1,4-dihydropyridine

There total 1 articles about 4-(2-chlorophenyl)-5-(2-cyanoethoxycarbonyl)-3-ethoxycarbonyl-6-methyl-2-(2-phtalimidoethoxymethyl)-1,4-dihydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-benzaldehyde (89-98-5) + ethyl 4-[2-(phthalimido)ethoxy]acetoacetate (88150-75-8) + (Z)-3-Amino-but-2-enoic acid 2-cyano-ethyl ester (193539-61-6) → 4-(2-chlorophenyl)-5-(2-cyanoethoxycarbonyl)-3-ethoxycarbonyl-6-methyl-2-(2-phtalimidoethoxymethyl)-1,4-dihydropyridine (120300-92-7)

Guidance literature:

With piperidine; In methanol; Ambient temperature; 1.) RT, 16 h, 2.) reflux, 4 h;

Reference yield:

4-(2-chlorophenyl)-5-(2-cyanoethoxycarbonyl)-3-ethoxycarbonyl-6-methyl-2-(2-phtalimidoethoxymethyl)-1,4-dihydropyridine (120300-92-7) → 4-(2-chlorophenyl)-5-(2-cyanoethoxycarbonyl)-3-ethoxycarbonyl-6-methyl-2-(2-phtalimidoethoxymethyl)pyridine (120289-19-2)

Guidance literature:

With sodium nitrite; In acetic acid; at 50 ℃; for 1h;

Reference yield:

4-(2-chlorophenyl)-5-(2-cyanoethoxycarbonyl)-3-ethoxycarbonyl-6-methyl-2-(2-phtalimidoethoxymethyl)-1,4-dihydropyridine (120300-92-7) → 2-(2-aminoethoxymethyl)-5-carboxy-4-(2-chlorophenyl)-3-ethoxycarbonyl-6-methyl-1,4-dihydropyridine

Guidance literature:

With methylamine; In water; for 5h; Ambient temperature;

upstream raw materials:

2-chloro-benzaldehyde

ethyl 4-[2-(phthalimido)ethoxy]acetoacetate

(Z)-3-Amino-but-2-enoic acid 2-cyano-ethyl ester

Downstream raw materials:

4-(2-chlorophenyl)-5-(2-cyanoethoxycarbonyl)-3-ethoxycarbonyl-6-methyl-2-(2-phtalimidoethoxymethyl)pyridine

2-(aminoethoxymethyl)-5-carboxy-4-(2-chlorophenyl)-3-ethoxycarbonyl-6-methylpyridine