3-[4-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phen yl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4-imidazolidinedione acetic acid salt

Base Information

Chemical Name:3-[4-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phen yl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4-imidazolidinedione acetic acid salt
CAS No.:457645-16-8
Molecular Formula:C₂H₄O₂*C₂₈H₃₉N₃O₆
Molecular Weight:573.687
Hs Code.:

3-[4-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phen yl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4-imidazolidinedione acetic acid salt

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Chemical Property of 3-[4-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phen yl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4-imidazolidinedione acetic acid salt

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Technology Process of 3-[4-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phen yl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4-imidazolidinedione acetic acid salt

There total 9 articles about 3-[4-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phen yl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4-imidazolidinedione acetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 457644-68-7
C₁₁H₁₃IN₂O₃

: 457645-16-8
3-[4-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phen yl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4-imidazolidinedione acetic acid salt

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / ethanol; water

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

3: N,N-dimethyl-formamide

4: platinum(IV) oxide; hydrogen / ethyl acetate / Enzymatic reaction

5: water / 75 °C

With platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide; 2: Sonogashira coupling;
DOI:10.1016/j.bmc.2011.05.064

Reference yield:

: 457643-96-8
3-(4-iodophenyl)-2,4-imidazolidinedione

: 457645-16-8
3-[4-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phen yl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4-imidazolidinedione acetic acid salt

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

2: N,N-dimethyl-formamide

3: platinum(IV) oxide; hydrogen / ethyl acetate / Enzymatic reaction

4: water / 75 °C

With platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; N-ethyl-N,N-diisopropylamine; In water; ethyl acetate; N,N-dimethyl-formamide; 1: Sonogashira coupling;
DOI:10.1016/j.bmc.2011.05.064

Reference yield:

: 208925-08-0
(2R)-hydroxy-2-(2,2-dimethyl-4H-1,3-benzodioxine-6-yl)-ethylamine

: 457645-16-8
3-[4-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phen yl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4-imidazolidinedione acetic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide

2: platinum(IV) oxide; hydrogen / ethyl acetate / Enzymatic reaction

3: water / 75 °C

With platinum(IV) oxide; hydrogen; In water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.05.064