4-CARBOXY-L-PHENYLALANINE

Base Information

• Chemical Name: 4-CARBOXY-L-PHENYLALANINE
• CAS No.: 126109-42-0
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.202
• Hs Code.: 2922499990
• Mol file: 126109-42-0.mol

Synonyms:H-PHE(P-COOH)-OH;H-P-CARBOXY-PHE-OH;P-CARBOXY-PHENYLALANINE;4-CARBOXYL-L-PHENYLALANINE;P-CARBOXY-L-PHENYLALANINE;L-(4-CARBOXY)PHENYLALANINE;H-PHE(4-COOH)-OH;

Chemical Property of 4-CARBOXY-L-PHENYLALANINE

Chemical Property:

• PSA: 100.62000
• LogP: 1.03950
• Storage Temp.: Store at RT.

Purity/Quality:

95% ^*data from raw suppliers

4-Carboxyphenylalanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CARBOXY-L-PHENYLALANINE

There total 12 articles about 4-CARBOXY-L-PHENYLALANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(S)-2-amino-3-(4-(methoxycarbonyl)phenyl)propanoic acid (473259-95-9,151872-17-2) → (S)-4-(2-amino-2-carboxyethyl)benzoic acid (24213-90-9,126109-42-0)

Guidance literature:

With lithium hydroxide monohydrate; In water; at 20 ℃; for 18h;

DOI:10.1021/acs.jmedchem.8b01007

Reference yield:

methyl 4-formylbenzoate (1571-08-0) → 4-carboxy-phenylalanine (22976-70-1,24213-90-9,126109-42-0)

Guidance literature:

Multi-step reaction with 3 steps

2: H₂; NH₃ / Pd/C / ethanol / 1810.02 - 2844.31 Torr

3: conc. HCl

With hydrogenchloride; ammonia; hydrogen; palladium on activated charcoal; In ethanol; 1: cyclocondensation / 2: Catalytic hydrogenation / 3: Hydrolysis;

DOI:10.1016/S0040-4020(00)00424-5

Reference yield:

4-[5-Oxo-2-phenyl-oxazol-(4E)-ylidenemethyl]-benzoic acid methyl ester (329023-63-4) → 4-carboxy-phenylalanine (22976-70-1,24213-90-9,126109-42-0)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂; NH₃ / Pd/C / ethanol / 1810.02 - 2844.31 Torr

2: conc. HCl

With hydrogenchloride; ammonia; hydrogen; palladium on activated charcoal; In ethanol; 1: Catalytic hydrogenation / 2: Hydrolysis;

DOI:10.1016/S0040-4020(00)00424-5

upstream raw materials:

methyl 4-formylbenzoate

4-[5-Oxo-2-phenyl-oxazol-(4E)-ylidenemethyl]-benzoic acid methyl ester

(S)-2-amino-3-(4-(methoxycarbonyl)phenyl)propanoic acid

C₁₁H₈N₂O₄

Refernces

• 1、 Chien, Huan-Chieh,Colas, Claire,Finke, Karissa,Springer, Seth,Stoner, Laura,Zur, Arik A.,Venteicher, Brooklynn,Campbell, Jerome,Hall, Colton,Flint, Andrew,Augustyn, Evan,Hernandez, Christopher,Heeren, Nathan,Hansen, Logan,Anthony, Abby,Bauer, Justine,Fotiadis, Dimitrios,Schlessinger, Avner,Giacomini, Kathleen M.,Thomas, Allen A.. "Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1)". supporting information. p. 7358 - 7373. Retrieved 2018/08/06.
• 2、 Sun, Yizhen,Martell, Arthur E.,Welch, Michael J.. "Synthesis of a new diaminodithiol bifunctional chelator for radiolabeling biomolecules with indium(III)". . p. 5093 - 5103. Retrieved 2007/10/03.