Technology Process of (3R, 6R)-1-(tert-butoxycarbonyl)-6-phenylpiperidine-3-carboxylic acid 1-(4-chlorophenyl)methaneamine
There total 5 articles about (3R, 6R)-1-(tert-butoxycarbonyl)-6-phenylpiperidine-3-carboxylic acid 1-(4-chlorophenyl)methaneamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: Rh(acac)2(CH2CH2)2; sodium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / 1,4-dioxane; water / 60 °C / Inert atmosphere
2: 20 % Pd(OH)2/C; hydrogen / ethanol / 18 h / 2327.23 Torr
3: sodium cyanoborohydride / methanol; acetic acid / 3 h / 20 °C / Inert atmosphere
4: 20 % Pd(OH)2/C; hydrogen; triethylamine / ethanol / 18 h / 2327.23 Torr / Inert atmosphere
5: water; sodium methylate / methanol / 18 h / 60 °C / Inert atmosphere
6: diethyl ether / Inert atmosphere
With
Rh(acac)2(CH2CH2)2; 20 % Pd(OH)2/C; water; hydrogen; sodium methylate; sodium cyanoborohydride; sodium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; triethylamine;
In
1,4-dioxane; methanol; diethyl ether; ethanol; water; acetic acid;
DOI:10.1021/ja111540g
- Guidance literature:
-
Multi-step reaction with 7 steps
1: isopropyl alcohol / 18 h / 20 °C / Inert atmosphere
2: Rh(acac)2(CH2CH2)2; sodium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / 1,4-dioxane; water / 60 °C / Inert atmosphere
3: 20 % Pd(OH)2/C; hydrogen / ethanol / 18 h / 2327.23 Torr
4: sodium cyanoborohydride / methanol; acetic acid / 3 h / 20 °C / Inert atmosphere
5: 20 % Pd(OH)2/C; hydrogen; triethylamine / ethanol / 18 h / 2327.23 Torr / Inert atmosphere
6: water; sodium methylate / methanol / 18 h / 60 °C / Inert atmosphere
7: diethyl ether / Inert atmosphere
With
Rh(acac)2(CH2CH2)2; 20 % Pd(OH)2/C; water; hydrogen; sodium methylate; sodium cyanoborohydride; sodium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; triethylamine;
In
1,4-dioxane; methanol; diethyl ether; ethanol; water; acetic acid; isopropyl alcohol;
DOI:10.1021/ja111540g
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium cyanoborohydride / methanol; acetic acid / 3 h / 20 °C / Inert atmosphere
2: 20 % Pd(OH)2/C; hydrogen; triethylamine / ethanol / 18 h / 2327.23 Torr / Inert atmosphere
3: water; sodium methylate / methanol / 18 h / 60 °C / Inert atmosphere
4: diethyl ether / Inert atmosphere
With
20 % Pd(OH)2/C; water; hydrogen; sodium methylate; sodium cyanoborohydride; triethylamine;
In
methanol; diethyl ether; ethanol; acetic acid;
DOI:10.1021/ja111540g
