6516-41-2

Usage

Uses

Used in Organic Synthesis:
Pyridinium, 3-(methoxycarbonyl)-1-(phenylmethyl)-, bromide is utilized as a catalyst or reagent in various chemical reactions, facilitating the formation of new molecules. Its unique structure allows it to participate in a range of organic transformations, making it a valuable component in the synthesis of complex organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, Pyridinium, 3-(methoxycarbonyl)-1-(phenylmethyl)-, bromide serves as an intermediate, contributing to the development of new drugs. Its potential biological activity is currently under investigation for possible therapeutic applications, highlighting its significance in the discovery and design of novel pharmaceutical agents.
Used in Catalyst Development:
Pyridinium, 3-(methoxycarbonyl)-1-(phenylmethyl)-, bromide is also employed in the development of catalysts for specific chemical reactions. Its ability to influence reaction pathways and improve yields makes it a promising candidate for enhancing the efficiency of chemical processes in various industries.

Upstream product

• 93-60-7 methyl 3-pyridinecarboxylate 
• 100-39-0 benzyl bromide 
• 57355-62-1 methyl 1-benzyl-1,4-dihydropyridine-3-carboxylate 
• 38559-35-2 3,10-dimethyl-5-deazaisoalloxazine 

Downstream Products

• 57355-62-1 methyl 1-benzyl-1,4-dihydropyridine-3-carboxylate 
• 38559-35-2 3,10-dimethyl-5-deazaisoalloxazine 
• 88928-69-2 1-benzyl-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid methyl ester 
• 75532-94-4 methyl 1-benzyl-1,4,5,6-tetrahydropyridine-3-carboxylate 
• 7146-29-4 1-benzyl-3-methoxycarbonyl-pyridinium; chloride 
• 288587-13-3 1-benzyl-2-formyl-pyrrolidine-2-carboxylic acid methyl ester 
• 288587-15-5 1-Benzyl-2-[(E)-benzylimino-methyl]-pyrrolidine-2-carboxylic acid methyl ester 
• 288587-17-7 1-benzyl-2-(benzylamino-methyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 1268249-88-2 methyl (6S)-1-benzyl-6-[(1E)-pent-1-en-1yl]-1,6-dihydropyridine-3-carboxylate 
• 1268249-87-1 methyl (6R)-1-benzyl-6-(4-fluorophenyl)-1,6-dihydropyridine-3-carboxylate 
• 1268249-81-5 methyl (6R)-1-benzyl-6-(2-methylphenyl)-1,6-dihydropyridine-3-carboxylate 
• 1268249-80-4 methyl (6R)-1-benzyl-6-(4-methylphenyl)-1,6-dihydropyridine-3-carboxylate 
• 1268249-86-0 methyl (6R)-1-benzyl-6-(4-chlorophenyl)-1,6-dihydropyridine-3-carboxylate 
• 1268249-82-6 methyl (6R)-1-benzyl-6-(4-methoxyphenyl)-1,6-dihydropyridine-3-carboxylate 

Relevant academic research and scientific papers

Development of small-molecule P-gp inhibitors of the N-benzyl 1,4-dihydropyridine type: Novel aspects in SAR and bioanalytical evaluation of multidrug resistance (MDR) reversal properties

Novel series of N-benzyl 1,4-dihydropyridines have been prepared by facile syntheses. All relevant substituents of the molecular scaffold have been varied. The resulting compounds were biologically evaluated as P-glycoprotein (P-gp) inhibitors. Substitutions of the N-benzyl residue favour biological activity beside respective 3-ester functions. Most active compounds were further evaluated as multidrug resistance (MDR) modulators to restore the cytotoxic properties of varying daunorubicin applications.

Rhodium-catalyzed enantioselective addition of boronic acids to N -benzylnicotinate salts

The highly enantioselective catalytic asymmetric addition of aryl and alkenylboronic acids to N-benzylnicotinate salt 1 is described. The dihydropyridine 2 reaction products can be converted to synthetically useful piperidines. Application of the methodol

Pyrrolidines bearing a quaternary α-stereogenic center. Part 2: Access to proline chimeras, stereoselective approach and mechanistic aspects

The present work describes the access to various proline chimeras bearing a quaternary α-stereogenic center, via the Duhamel ring contraction of heterocyclic enamines. Attempts to induce diastereoselectivity are reported. The 'chiral enamine' strategy aff

Structure Sensitivity of the Marcus λ for Hydride Transfer between NAD+ Analogues

Thirty-five rate constants, kij, for transfer of hydride between various pyridinium, quinilinium, acridinium, and phenantridinium ions spanning a range of over 10E11 in their equilibrium constants Kij and over 10E6 in kij

Marcus Theory of Hydride Transfer from an Anionic reduced Deazaflavin to NAD+ Analogues

Eighteen rate constants, kij for hydride transfer from the conjugate base of 1,5-dihydro-3,10-dimethyl-5-diazaisoalloxazine to a variety of pyridinium, quinolinium, phenanthridinium, and acridinium ions have been determined. (All the oxidizing agents can be regarded as analogues of NAD+.) The kij values span 7 powers of 10 and the corresponding equilibrium constants, Kij, span more than 13 powers of 10.For reactions with ΔG0 near zero, the kij values are close to those given by modified Marcus theory (ref 10).However, with more negative ΔG0 values, the observed kij increase more strogly than the calculated values.Agreement can be produced by making the standard free energy of precursor complex formation, symbolized WT +- here, to indicate that it applies to reactants of opposite charge, a linear function of ΔG0, and treating the slope and interrcept of the linear relation as adjustable parameters.The best fit is obtained with WT+-(in kJ*mol-1)=-9.4+0.11ΔG0.An avarage discrepancy between calculated and observed ln kij values of 0.5 is achieved, which is a good as the overall fit achieved for hydride transfer from neutral NADH analogues to NAD+ analogues (ref 10).The form and the parameterization of Wf are shown to be a physically reasonable approximation for reactions with ΔG00.These results strengthen the conclusion (ref 10) that a wide range of hydride transfer rates can be quantitavely understood without introducing high-energy metastable intermediates (radicals and radical ions).