4-[4-(2-carboxymethyl-3-oxo-4-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-8-yl)-but-3-enyl]-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-[4-(2-carboxymethyl-3-oxo-4-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-8-yl)-but-3-enyl]-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:223587-32-4
Molecular Formula:C₃₃H₄₃N₃O₅
Molecular Weight:561.722
Hs Code.:

4-[4-(2-carboxymethyl-3-oxo-4-phenethyl-2,3,4,5-tetrahydro-1<i>H</i>-benzo[<i>e</i>][1,4]diazepin-8-yl)-but-3-enyl]-piperidine-1-carboxylic acid <i>tert</i>-butyl ester

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Chemical Property of 4-[4-(2-carboxymethyl-3-oxo-4-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-8-yl)-but-3-enyl]-piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-[4-(2-carboxymethyl-3-oxo-4-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-8-yl)-but-3-enyl]-piperidine-1-carboxylic acid tert-butyl ester

There total 3 articles about 4-[4-(2-carboxymethyl-3-oxo-4-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-8-yl)-but-3-enyl]-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 165529-90-8
methyl (R,S)-8-<4--1(E)-butenyl>-2,3,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-1H-1,4-benzodiazepine-2-acetate

: 223587-32-4
4-[4-(2-carboxymethyl-3-oxo-4-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-8-yl)-but-3-enyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; Ambient temperature;
DOI:10.1021/jm980166z

Reference yield:

: 156185-63-6
N-Boc-piperidin-4-yl-propanol

: 223587-32-4
4-[4-(2-carboxymethyl-3-oxo-4-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-8-yl)-but-3-enyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) (COCl)2, Me₂SO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) CH₂Cl₂, RT, 16 h

2: NaH / tetrahydrofuran / 16 h

3: 1N aq. NaOH / dioxane / Ambient temperature

With sodium hydroxide; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jm980166z

Reference yield:

: 165528-85-8
1,1-dimethylethyl 4-(3-oxopropyl)-1-piperidinecarboxylate

: 223587-32-4
4-[4-(2-carboxymethyl-3-oxo-4-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-8-yl)-but-3-enyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / tetrahydrofuran / 16 h

2: 1N aq. NaOH / dioxane / Ambient temperature

With sodium hydroxide; sodium hydride; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jm980166z