Tert-butyl 4-(3-oxopropyl)piperidine-1-carboxylate

Base Information

Chemical Name:Tert-butyl 4-(3-oxopropyl)piperidine-1-carboxylate
CAS No.:165528-85-8
Molecular Formula:C13H23NO3
Molecular Weight:241.331
Hs Code.:2933399090
European Community (EC) Number:846-592-1
DSSTox Substance ID:DTXSID80443153
Nikkaji Number:J2.255.325I
Wikidata:Q82260865
Mol file:165528-85-8.mol

Synonyms:165528-85-8;Tert-butyl 4-(3-oxopropyl)piperidine-1-carboxylate;1-BOC-4-(3-OXOPROPYL)PIPERIDINE;SCHEMBL1576006;DTXSID80443153;KJGPCTZYGOOHBK-UHFFFAOYSA-N;MFCD09910237;AKOS015897733;1-(tert-Butoxycarbonyl)piperidine-4-propanal;FT-0709340;3-(N-t-Butyloxycarbonylpiperidin-4-yl)propanal;C77531;EN300-263262;t-Butyl 4-(3-oxopropyl)piperidine-1-carboxylate;Tert-butyl4-(3-oxopropyl)piperidine-1-carboxylate;3-[N-(t-butoxycarbonyl)piperidin-4-yl]propionaldehyde;Z1505710186;1,1-dimethylethyl 4-(3-oxopropyl)-1-piperidinecarboxylate;4-(3-oxopropyl)piperidine-1-carboxylic acid tert-butyl ester

Suppliers and Price of Tert-butyl 4-(3-oxopropyl)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
TERT-BUTYL-4-(3-OXOPROPYL)PIPERIDINE-1-CARBOXYLATE 95.00%
5MG
$ 498.03

AK Scientific
Tert-butyl4-(3-oxopropyl)piperidine-1-carboxylate
2.5g
$ 1826.00

AK Scientific
Tert-butyl4-(3-oxopropyl)piperidine-1-carboxylate
1g
$ 994.00

AK Scientific
Tert-butyl4-(3-oxopropyl)piperidine-1-carboxylate
100mg
$ 379.00

Activate Scientific
1-Boc-4-(3-oxopropyl)piperidine 97%
250 mg
$ 259.00

Acrotein
1-Boc-4-(3-oxopropyl)piperidine 97%
1g
$ 412.50

Total 7 raw suppliers

Chemical Property of Tert-butyl 4-(3-oxopropyl)piperidine-1-carboxylate

Chemical Property:

Boiling Point:334.0±15.0 °C(Predicted)
PKA:-1.41±0.40(Predicted)
PSA：46.61000
Density:1.022±0.06 g/cm3(Predicted)
LogP:2.55050
XLogP3:1.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:241.16779360
Heavy Atom Count:17
Complexity:262

Purity/Quality:

98% ^*data from raw suppliers

TERT-BUTYL-4-(3-OXOPROPYL)PIPERIDINE-1-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1)CCC=O

Technology Process of Tert-butyl 4-(3-oxopropyl)piperidine-1-carboxylate

There total 7 articles about Tert-butyl 4-(3-oxopropyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 156185-63-6
N-Boc-piperidin-4-yl-propanol

: 165528-85-8
1,1-dimethylethyl 4-(3-oxopropyl)-1-piperidinecarboxylate

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 1h; Temperature; Inert atmosphere;

Reference yield: 87.0%

: 79-37-8
oxalyl dichloride

: 156185-63-6
N-Boc-piperidin-4-yl-propanol

: 165528-85-8
1,1-dimethylethyl 4-(3-oxopropyl)-1-piperidinecarboxylate

Guidance literature:: With triethylamine; In dichloromethane; dimethyl sulfoxide;

Reference yield:

: 2629-72-3
4-(3-Hydroxypropyl)pyridine

: 165528-85-8
1,1-dimethylethyl 4-(3-oxopropyl)-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / H₂; AcOH / 10percent Pd/C / 20 °C / 2585.81 Torr

2: 92 percent / 1N NaOH / dioxane

3: 95 percent / (COCl)2; DMSO / CH₂Cl₂ / -78 °C

With sodium hydroxide; oxalyl dichloride; hydrogen; acetic acid; dimethyl sulfoxide; 10percent Pd/C; In 1,4-dioxane; dichloromethane; 3: Swern oxidation;
DOI:10.1021/ol010282n