methyl 3N-benzylaminododecanoate

Base Information

Chemical Name:methyl 3N-benzylaminododecanoate
CAS No.:172941-42-3
Molecular Formula:C₂₀H₃₃NO₂
Molecular Weight:319.488
Hs Code.:

Synonyms:

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Chemical Property of methyl 3N-benzylaminododecanoate

Chemical Property:

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Technology Process of methyl 3N-benzylaminododecanoate

There total 2 articles about methyl 3N-benzylaminododecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 6208-91-9
methyl (E)-dodec-2-enolate

: 100-46-9
benzylamine

: 172941-42-3
methyl 3N-benzylaminododecanoate

Guidance literature:: In ethanol; for 22h; Heating;
DOI:10.7164/antibiotics.52.710

Reference yield:

: 112-31-2
caprinaldehyde

: 172941-42-3
methyl 3N-benzylaminododecanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 70.9 percent / benzene / 7 h / Heating

2: 43 percent / ethanol / 22 h / Heating

In ethanol; benzene; 1: Wittig reaction / 2: Addition;
DOI:10.7164/antibiotics.52.710

Reference yield:

: 172941-42-3
methyl 3N-benzylaminododecanoate

: Gly-L-Lys(Z)-L-Val-3(R)-aminododecanoic acid, TFA salt

Guidance literature:: Multi-step reaction with 6 steps

1: 99.7 percent / H₂ / 20 percent Pd(OH)2/C / methanol / 22.5 h / 20 °C

2: 21.8 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 16 h / -20 - 20 °C

3: 100 percent / TFA / CH₂Cl₂ / 1.25 h / 0 °C

4: 93.6 percent / Et₃N; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt (1-hydroxybenzotriazole) / tetrahydrofuran / 2.75 h / -5 °C

5: 86.6 percent / aq. LiOH / tetrahydrofuran; methanol / 5 h / 20 °C

6: 100 percent / TFA / CH₂Cl₂ / 0.58 h / 20 °C

With lithium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; 1: Catalytic hydrogenation / 2: Acylation / 3: deprotection / 4: Acylation / 5: Hydrolysis / 6: deprotection;
DOI:10.7164/antibiotics.52.710