(S)-3-(4-(3-(6-(3-mercaptopropanamido)hexanamido)propoxy)benzamido)-4-(4-(3-((4-methoxypyridin-2-yl)amino)propoxy)phenyl)butanoic acid

Base Information

• Chemical Name: (S)-3-(4-(3-(6-(3-mercaptopropanamido)hexanamido)propoxy)benzamido)-4-(4-(3-((4-methoxypyridin-2-yl)amino)propoxy)phenyl)butanoic acid
• CAS No.: 1426302-52-4
• Molecular Formula: C₃₈H₅₁N₅O₈S
• Molecular Weight: 737.918
• Mol file: 1426302-52-4.mol

Synonyms:

Chemical Property of (S)-3-(4-(3-(6-(3-mercaptopropanamido)hexanamido)propoxy)benzamido)-4-(4-(3-((4-methoxypyridin-2-yl)amino)propoxy)phenyl)butanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-(4-(3-(6-(3-mercaptopropanamido)hexanamido)propoxy)benzamido)-4-(4-(3-((4-methoxypyridin-2-yl)amino)propoxy)phenyl)butanoic acid

There total 8 articles about (S)-3-(4-(3-(6-(3-mercaptopropanamido)hexanamido)propoxy)benzamido)-4-(4-(3-((4-methoxypyridin-2-yl)amino)propoxy)phenyl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C58H67N5O8S → (S)-3-(4-(3-(6-(3-mercaptopropanamido)hexanamido)propoxy)benzamido)-4-(4-(3-((4-methoxypyridin-2-yl)amino)propoxy)phenyl)butanoic acid (1426302-52-4)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium hydroxide; water / methanol / 20 °C

2: trifluoroacetic acid / dichloromethane / 0.5 h

With water; trifluoroacetic acid; lithium hydroxide; In methanol; dichloromethane;

DOI:10.1002/anie.201206370

Reference yield:

(S)-methyl 3-((tert-butoxycarbonyl)amino)-4-(4-(3-((4-methoxypyridin-2-yl)amino)propoxy)phenyl)butanoate (1426302-58-0) → (S)-3-(4-(3-(6-(3-mercaptopropanamido)hexanamido)propoxy)benzamido)-4-(4-(3-((4-methoxypyridin-2-yl)amino)propoxy)phenyl)butanoic acid (1426302-52-4)

Guidance literature:

Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 0.5 h

2: HATU; 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

3: lithium hydroxide; water / methanol / 20 °C

4: trifluoroacetic acid / dichloromethane / 0.5 h

With 1-hydroxy-7-aza-benzotriazole; water; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/anie.201206370

Reference yield:

(S)-methyl 3-((tert-butoxycarbonyl)amino)-4-(4-(3-hydroxypropoxy)phenyl)butanoate (1426302-56-8) → (S)-3-(4-(3-(6-(3-mercaptopropanamido)hexanamido)propoxy)benzamido)-4-(4-(3-((4-methoxypyridin-2-yl)amino)propoxy)phenyl)butanoic acid (1426302-52-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 6 h / 20 °C

2: magnesium sulfate monohydrate / dichloromethane / 1 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 0.5 h

4: HATU; 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

5: lithium hydroxide; water / methanol / 20 °C

6: trifluoroacetic acid / dichloromethane / 0.5 h

With 1-hydroxy-7-aza-benzotriazole; magnesium sulfate monohydrate; water; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1002/anie.201206370

upstream raw materials:

(S)-methyl 3-((tert-butoxycarbonyl)amino)-4-(4-(3-hydroxypropoxy)phenyl)butanoate

((S)-methyl 3-(tert-Butoxycarbonyl)amino)-4-(4-(3-oxopropoxy)phenyl)butanoate

(S)-methyl 3-((tert-butoxycarbonyl)amino)-4-(4-(3-((4-methoxypyridin-2-yl)amino)propoxy)phenyl)butanoate

N-tert-butyloxycarbonyl-β-homotyrosine methyl ester