(S)-3-<<1-(cyclohexylmethyl)-3,3-difluoro-4-<<2-(4-morpholino)ethyl>amino>-2,4-dioxobutyl>amino>-N--3-oxo-DL-alanine methyl ester methanesulfonate

Base Information

Chemical Name:(S)-3-<<1-(cyclohexylmethyl)-3,3-difluoro-4-<<2-(4-morpholino)ethyl>amino>-2,4-dioxobutyl>amino>-N--3-oxo-DL-alanine methyl ester methanesulfonate
CAS No.:134334-94-4
Molecular Formula:C₃₄H₅₀F₂N₆O₁₀S
Molecular Weight:772.868
Hs Code.:

(S)-3-<<1-(cyclohexylmethyl)-3,3-difluoro-4-<<2-(4-morpholino)ethyl>amino>-2,4-dioxobutyl>amino>-N-<N-(4-morpholinosulfonyl)-L-phenylalanyl>-3-oxo-DL-alanine methyl ester methanesulfonate

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Chemical Property of (S)-3-<<1-(cyclohexylmethyl)-3,3-difluoro-4-<<2-(4-morpholino)ethyl>amino>-2,4-dioxobutyl>amino>-N--3-oxo-DL-alanine methyl ester methanesulfonate

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Technology Process of (S)-3-<<1-(cyclohexylmethyl)-3,3-difluoro-4-<<2-(4-morpholino)ethyl>amino>-2,4-dioxobutyl>amino>-N--3-oxo-DL-alanine methyl ester methanesulfonate

There total 12 articles about (S)-3-<<1-(cyclohexylmethyl)-3,3-difluoro-4-<<2-(4-morpholino)ethyl>amino>-2,4-dioxobutyl>amino>-N--3-oxo-DL-alanine methyl ester methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 134334-93-3,134452-00-9
3-<<1(S)-(cyclohexylmethyl)-3,3-difluoro-2(R)-hydoxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>amino>-N--3-oxo-DL-alanine methyl ester

: 134334-94-4,134453-04-6
(S)-3-<<1-(cyclohexylmethyl)-3,3-difluoro-4-<<2-(4-morpholino)ethyl>amino>-2,4-dioxobutyl>amino>-N--3-oxo-DL-alanine methyl ester methanesulfonate

Guidance literature:: With dichloro-acetic acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide; In dichloromethane; 1.) 0 deg C, 2.) RT, 18 h;
DOI:10.1021/jm00079a001

Reference yield:

: 124278-39-3
N-(4-MorpholinYlsulfonyl)-L-phenylalanine

: 134334-94-4,134453-04-6
(S)-3-<<1-(cyclohexylmethyl)-3,3-difluoro-4-<<2-(4-morpholino)ethyl>amino>-2,4-dioxobutyl>amino>-N--3-oxo-DL-alanine methyl ester methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / dicyclohexylcarbodiimide, HOBT, triethylamine / CH₂Cl₂; dimethylformamide

2: 97.4 percent / H₂ / 20percent Pd/C / methanol / 2 h

3: 34 percent / HOBT, dicyclohexylcarbodiimide / CH₂Cl₂ / 1.) 0 deg C - RT, overnight, 2.) RT, 38 h

4: 86 percent / 1.) dichloroacetic acid, DMSO, dicyclohexylcarbodiimide, 2.) oxalic acid / 1.) CH₂Cl₂, a) 0 deg C - RT, overnight, b) RT, 24 h, 2.) CH₂Cl₂, metanol, 30 min

With dichloro-acetic acid; hydrogen; oxalic acid; benzotriazol-1-ol; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00111a002

Reference yield:

: 127953-31-5
2-[(S)-2-(Morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-malonic acid benzyl ester methyl ester

: 134334-94-4,134453-04-6
(S)-3-<<1-(cyclohexylmethyl)-3,3-difluoro-4-<<2-(4-morpholino)ethyl>amino>-2,4-dioxobutyl>amino>-N--3-oxo-DL-alanine methyl ester methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: 97.4 percent / H₂ / 20percent Pd/C / methanol / 2 h

2: 34 percent / HOBT, dicyclohexylcarbodiimide / CH₂Cl₂ / 1.) 0 deg C - RT, overnight, 2.) RT, 38 h

3: 86 percent / 1.) dichloroacetic acid, DMSO, dicyclohexylcarbodiimide, 2.) oxalic acid / 1.) CH₂Cl₂, a) 0 deg C - RT, overnight, b) RT, 24 h, 2.) CH₂Cl₂, metanol, 30 min

With dichloro-acetic acid; hydrogen; oxalic acid; benzotriazol-1-ol; dimethyl sulfoxide; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00111a002