diethyl N-<4--N-prop-2-ynylamino>-2,3,5,6-tetrafluorobenzoyl>-L-glutamate

Base Information

Chemical Name:diethyl N-<4--N-prop-2-ynylamino>-2,3,5,6-tetrafluorobenzoyl>-L-glutamate
CAS No.:146698-37-5
Molecular Formula:C₂₉H₂₈F₄N₄O₆
Molecular Weight:604.558
Hs Code.:

diethyl N-<4-<N-<(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl>-N-prop-2-ynylamino>-2,3,5,6-tetrafluorobenzoyl>-L-glutamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl N-<4--N-prop-2-ynylamino>-2,3,5,6-tetrafluorobenzoyl>-L-glutamate

Chemical Property:

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Technology Process of diethyl N-<4--N-prop-2-ynylamino>-2,3,5,6-tetrafluorobenzoyl>-L-glutamate

There total 4 articles about diethyl N-<4--N-prop-2-ynylamino>-2,3,5,6-tetrafluorobenzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 112888-43-4
4(3H)-oxo-6-(bromomethyl)-2-methyl quinazoline

: 146698-36-4
diethyl N-<4-(prop-2-ynylamino)-2,3,5,6-tetrafluorobenzoyl>-L-glutamate

: 146698-37-5
diethyl N-<4--N-prop-2-ynylamino>-2,3,5,6-tetrafluorobenzoyl>-L-glutamate

Guidance literature:: With caesium carbonate; In acetonitrile; at 80 ℃; for 16h;
DOI:10.1016/S0022-1139(00)82191-0

Reference yield:

: 944-43-4
4-amino-2,3,5,6-tetrafluorobenzoic acid

: 146698-37-5
diethyl N-<4--N-prop-2-ynylamino>-2,3,5,6-tetrafluorobenzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / toluene / 3 h / Heating

2: Et₃N / CH₂Cl₂ / 1 h / 25 °C

3: 31.5 percent / Cs₂CO₃ / toluene; acetonitrile / 3 h / 80 °C

4: 20 percent / Cs₂CO₃ / acetonitrile / 16 h / 80 °C

With thionyl chloride; caesium carbonate; triethylamine; In dichloromethane; toluene; acetonitrile;
DOI:10.1016/S0022-1139(00)82191-0

Reference yield:

: 146698-38-6
2,3,5,6-tetrafluoro-4-sulfinylaminobenzoyl chloride

: 146698-37-5
diethyl N-<4--N-prop-2-ynylamino>-2,3,5,6-tetrafluorobenzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 1 h / 25 °C

2: 31.5 percent / Cs₂CO₃ / toluene; acetonitrile / 3 h / 80 °C

3: 20 percent / Cs₂CO₃ / acetonitrile / 16 h / 80 °C

With caesium carbonate; triethylamine; In dichloromethane; toluene; acetonitrile;
DOI:10.1016/S0022-1139(00)82191-0