bromo-2 exo benzoyloxy-7 syn bicyclo<2.2.1>heptane

Base Information

• Chemical Name: bromo-2 exo benzoyloxy-7 syn bicyclo<2.2.1>heptane
• CAS No.: 77085-38-2
• Molecular Formula: C₁₄H₁₅BrO₂
• Molecular Weight: 295.176
• Mol file: 77085-38-2.mol

Synonyms:

Chemical Property of bromo-2 exo benzoyloxy-7 syn bicyclo<2.2.1>heptane

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of bromo-2 exo benzoyloxy-7 syn bicyclo<2.2.1>heptane

There total 19 articles about bromo-2 exo benzoyloxy-7 syn bicyclo<2.2.1>heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

benzoyl chloride (98-88-4) + bromo-2 exo hydroxy-7 syn bicyclo<2.2.1>heptane (31337-62-9,101011-79-4) → bromo-2 exo benzoyloxy-7 syn bicyclo<2.2.1>heptane (77085-38-2,77085-39-3,77085-40-6)

Guidance literature:

With pyridine; In benzene; Ambient temperature;

DOI:10.1016/0040-4020(80)80151-7

Reference yield: 29.5%

dioxa-3,5 exo phenyl-4 syn tricyclo<5.2.1.02,6>decane (31112-52-4) → Benzoic acid (1S,2R,4S)-2-bromo-bicyclo[2.2.1]hept-7-yl ester (77085-38-2,77085-39-3,77085-40-6) + Benzoic acid (1S,2S,4S,7R)-2-bromo-bicyclo[2.2.1]hept-7-yl ester + Benzoic acid (1R,2R,4R,7R)-2-bromo-bicyclo[2.2.1]hept-7-yl ester + (+/-)-(1R,2S,3R,4S)-3-hydroxybicyclo[2.2.1]heptan-2-yl benzoate (77085-41-7) + bromo-2 endo benzoyloxy-3 exo bicyclo<2.2.1>heptane (77085-37-1,77341-49-2)

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane; for 3h; Product distribution; Heating; variation of time and quantity of NBS;

DOI:10.1016/0040-4020(80)80152-9

Reference yield: 16.0%

(+/-)-(1R,2S,3R,4S)-3-hydroxybicyclo[2.2.1]heptan-2-yl benzoate (77085-41-7) → bromo-2 exo benzoyloxy-7 syn bicyclo<2.2.1>heptane (77085-38-2,77085-39-3,77085-40-6) + bromo-2 endo benzoyloxy-3 exo bicyclo<2.2.1>heptane (77085-37-1,77341-49-2)

Guidance literature:

With hydrogen bromide; In tetrachloromethane; for 20h; Heating;

DOI:10.1016/S0040-4020(01)97946-3

upstream raw materials:

N-Bromosuccinimide

dioxa-3,5 exo phenyl-4 syn tricyclo<5.2.1.0^2,6>decane

trityl tetrafluoroborate

benzoyl chloride