Acetic acid 2-[(1R,3R,6R)-3-(3-hydroxy-propyl)-2,2,6-trimethyl-cyclohexyl]-ethyl ester

Base Information

Chemical Name:Acetic acid 2-[(1R,3R,6R)-3-(3-hydroxy-propyl)-2,2,6-trimethyl-cyclohexyl]-ethyl ester
CAS No.:123887-63-8
Molecular Formula:C₁₆H₃₀O₃
Molecular Weight:270.412
Hs Code.:

Synonyms:

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Chemical Property of Acetic acid 2-[(1R,3R,6R)-3-(3-hydroxy-propyl)-2,2,6-trimethyl-cyclohexyl]-ethyl ester

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Technology Process of Acetic acid 2-[(1R,3R,6R)-3-(3-hydroxy-propyl)-2,2,6-trimethyl-cyclohexyl]-ethyl ester

There total 14 articles about Acetic acid 2-[(1R,3R,6R)-3-(3-hydroxy-propyl)-2,2,6-trimethyl-cyclohexyl]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123887-62-7
Acetic acid 2-{(1R,3R,6R)-2,2,6-trimethyl-3-[3-(tetrahydro-pyran-2-yloxy)-propyl]-cyclohexyl}-ethyl ester

: 123887-63-8
Acetic acid 2-[(1R,3R,6R)-3-(3-hydroxy-propyl)-2,2,6-trimethyl-cyclohexyl]-ethyl ester

Guidance literature:: With toluene-4-sulfonic acid; In ethanol; for 3h; Yield given; Ambient temperature;
DOI:10.1248/cpb.36.4711

Reference yield:

: 123887-37-6,123906-77-4
bicyclic hemiacetal of 4α-formyl-6α-hydroxymethyl-1,5,5-trimethylcyclohexene

: 123887-63-8
Acetic acid 2-[(1R,3R,6R)-3-(3-hydroxy-propyl)-2,2,6-trimethyl-cyclohexyl]-ethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 70.5 percent / toluene / 24 h / 100 °C

2: 97.3 percent / PtO₂, hydrogen / ethyl acetate / 2 h / Ambient temperature

3: 100 percent / Et₃N / CH₂Cl₂ / 0.33 h / 0 °C

4: dimethylsulfoxide / 7 h / 100 - 105 °C

5: 240 mg / LiBH₄ / diethyl ether / 3 h / Heating

6: pyridinium p-toluenesulfonate / CH₂Cl₂ / 13 h / Ambient temperature

7: 185 mg / diisobutylaluminum hydride / hexane; toluene / 1 h / Ambient temperature

8: 176 mg / 1.) LiAlH₄; 2.) NaOH, water / diethyl ether / 0.5 h / -15 °C

9: 179 mg / pyridine / 1 h / Ambient temperature

10: p-TsOH / ethanol / 3 h / Ambient temperature

With platinum(IV) oxide; sodium hydroxide; lithium aluminium tetrahydride; lithium borohydride; water; hydrogen; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; toluene-4-sulfonic acid; triethylamine; In pyridine; diethyl ether; ethanol; hexane; dichloromethane; dimethyl sulfoxide; ethyl acetate; toluene;
DOI:10.1248/cpb.36.4711

Reference yield:

: 123887-47-8
3-(3α-cyanomethyl-2,2,4α-trimethylcyclohexan-1α-yl)propan-1-ol

: 123887-63-8
Acetic acid 2-[(1R,3R,6R)-3-(3-hydroxy-propyl)-2,2,6-trimethyl-cyclohexyl]-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: pyridinium p-toluenesulfonate / CH₂Cl₂ / 13 h / Ambient temperature

2: 185 mg / diisobutylaluminum hydride / hexane; toluene / 1 h / Ambient temperature

3: 176 mg / 1.) LiAlH₄; 2.) NaOH, water / diethyl ether / 0.5 h / -15 °C

4: 179 mg / pyridine / 1 h / Ambient temperature

5: p-TsOH / ethanol / 3 h / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; water; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; toluene-4-sulfonic acid; In pyridine; diethyl ether; ethanol; hexane; dichloromethane; toluene;
DOI:10.1248/cpb.36.4711