3-<2-methyl-3-methoxy-5-<(4R)-isopropyl-3,6-dimethoxypyrazinyl>phenyloxy>

Base Information

• Chemical Name: 3-<2-methyl-3-methoxy-5-<(4R)-isopropyl-3,6-dimethoxypyrazinyl>phenyloxy>
• CAS No.: 144864-82-4
• Molecular Formula: C₃₂H₄₃N₃O₉
• Molecular Weight: 613.708

Synonyms:

Chemical Property of 3-<2-methyl-3-methoxy-5-<(4R)-isopropyl-3,6-dimethoxypyrazinyl>phenyloxy>

Chemical Property:

Purity/Quality:

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Technology Process of 3-<2-methyl-3-methoxy-5-<(4R)-isopropyl-3,6-dimethoxypyrazinyl>phenyloxy>

There total 2 articles about 3-<2-methyl-3-methoxy-5-<(4R)-isopropyl-3,6-dimethoxypyrazinyl>phenyloxy> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-chloro-3-methoxy-2-methylbenzene (3260-88-6) + (2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine (109838-85-9) + methyl (2R)-<<(1,1-dimethylethoxy)carbonyl>amino>-2-(3-hydroxy-4-methoxyphenyl)acetate (144864-73-3) → (S)-tert-Butoxycarbonylamino-[4-methoxy-3-(3-methoxy-2-methyl-phenoxy)-phenyl]-acetic acid methyl ester (144864-81-3) + 3-(2-methyl-3-methoxyphenyloxy) methyl ester (144864-81-3) + 3-<2-methyl-3-methoxy-5-<(4R)-isopropyl-3,6-dimethoxypyrazinyl>phenyloxy> (144864-82-4) + (R)-tert-Butoxycarbonylamino-{3-[5-((2R,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-3-methoxy-2-methyl-phenoxy]-4-methoxy-phenyl}-acetic acid methyl ester (144864-82-4)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1016/S0040-4020(01)90366-7

Reference yield:

1-chloro-3-methoxy-2-methylbenzene (3260-88-6) + (2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine (109838-85-9) + methyl (2R)-<<(1,1-dimethylethoxy)carbonyl>amino>-2-(3-hydroxy-4-methoxyphenyl)acetate (144864-73-3) → (S)-tert-Butoxycarbonylamino-[4-methoxy-3-(3-methoxy-2-methyl-phenoxy)-phenyl]-acetic acid methyl ester (144864-81-3) + 3-(2-methyl-3-methoxyphenyloxy) methyl ester (144864-81-3) + 3-<2-methyl-3-methoxy-5-<(4R)-isopropyl-3,6-dimethoxypyrazinyl>phenyloxy> (144864-82-4) + (R)-tert-Butoxycarbonylamino-{3-[5-((2R,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-3-methoxy-2-methyl-phenoxy]-4-methoxy-phenyl}-acetic acid methyl ester (144864-82-4)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1016/S0040-4020(01)90366-7

Reference yield:

3-<2-methyl-3-methoxy-5-<(4R)-isopropyl-3,6-dimethoxypyrazinyl>phenyloxy> (144864-82-4) → (S)-Amino-{3-[5-((R)-tert-butoxycarbonylamino-methoxycarbonyl-methyl)-2-methoxy-phenoxy]-5-methoxy-4-methyl-phenyl}-acetic acid methyl ester; hydrochloride

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 1.5h; Ambient temperature;

DOI:10.1016/S0040-4020(01)90366-7

upstream raw materials:

1-chloro-3-methoxy-2-methylbenzene

(2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine

methyl (2R)-<<(1,1-dimethylethoxy)carbonyl>amino>-2-(3-hydroxy-4-methoxyphenyl)acetate

Downstream raw materials:

-O-

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