4-Pentene-1,3-dione, 1-(2-hydroxyphenyl)-5-phenyl-, (4E)-

Base Information

• Chemical Name: 4-Pentene-1,3-dione, 1-(2-hydroxyphenyl)-5-phenyl-, (4E)-
• CAS No.: 126525-72-2
• Molecular Formula: C17H14O3
• Molecular Weight: 266.296
• Mol file: 126525-72-2.mol

Synonyms:1-(2-Hydroxy-phenyl)-5t-phenyl-pent-4-en-1,3-dion;1-(2-hydroxy-phenyl)-5t-phenyl-pent-4-ene-1,3-dione;cinnamoyl(2-hydroxybenzoyl)methane;(E)-1-(2-Hydroxy-phenyl)-5-phenyl-pent-4-ene-1,3-dione;

Chemical Property of 4-Pentene-1,3-dione, 1-(2-hydroxyphenyl)-5-phenyl-, (4E)-

Chemical Property:

• PSA: 54.37000
• LogP: 3.24750

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Pentene-1,3-dione, 1-(2-hydroxyphenyl)-5-phenyl-, (4E)-

There total 5 articles about 4-Pentene-1,3-dione, 1-(2-hydroxyphenyl)-5-phenyl-, (4E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

o-hydroxyacetophenone (118-93-4,104809-67-8) + Cinnamoyl chloride (102-92-1,17082-09-6) → 1-(2-hydroxyphenyl)-5-phenyl-4-pentene-1,3-dione (126525-72-2)

Guidance literature:

o-hydroxyacetophenone; Cinnamoyl chloride; With activated Ba(OH)₂; In ethanol; water; for 0.5h; Irradiation; Green chemistry;

Green chemistry;

DOI:10.1134/S1070428020120155

Reference yield:

2-acetylphenyl (E)-3-phenylacrylate (74766-95-3) → 1-(2-hydroxyphenyl)-5-phenyl-4-pentene-1,3-dione (126525-72-2)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 14h;

DOI:10.1021/acs.jmedchem.7b00991

Reference yield:

o-hydroxyacetophenone (118-93-4,104809-67-8) → 1-(2-hydroxyphenyl)-5-phenyl-4-pentene-1,3-dione (126525-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 2 h / 0 - 60 °C

2: potassium hydroxide / dimethyl sulfoxide / 14 h / 20 °C

With pyridine; potassium hydroxide; In dimethyl sulfoxide;

DOI:10.1021/acs.jmedchem.7b00991

upstream raw materials:

Cinnamoyl chloride

o-hydroxyacetophenone

2-acetylphenyl (E)-3-phenylacrylate

Downstream raw materials:

(E)-5⁽³⁾-(2-hydroxyphenyl)-3⁽⁵⁾-styrylpyrazole

5-(2-hydroxyphenyl)-1-phenyl-3-styrylpyrazole

5-(2-hydroxyphenyl)-1-phenyl-3-[2-(3-phenyl-1,2,3,4-tetrahydronaphthyl)]pyrazole

(E)-2-styrylchromone