Technology Process of N-[1-(4-hydroxy-3-isopropylbenzyl)-1H-indol-4-yl]oxamic acid
There total 8 articles about N-[1-(4-hydroxy-3-isopropylbenzyl)-1H-indol-4-yl]oxamic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C
2.1: n-butyllithium / tetrahydrofuran; pentane / 2 h / -78 °C
2.2: 4 h / -78 - 20 °C
3.1: thionyl chloride / dichloromethane / 2 h / 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 5 °C
4.2: 3 h / 5 °C
5.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 3 h / 20 °C
6.1: 3 h / 100 °C
7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
8.1: sodium hydroxide / ethanol / 1 h / 20 °C
With
1H-imidazole; n-butyllithium; thionyl chloride; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil; pentane;
DOI:10.1016/j.bmc.2013.11.001
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: N-Bromosuccinimide / acetonitrile / 4 h / 0 - 20 °C
2.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C
3.1: n-butyllithium / tetrahydrofuran; pentane / 2 h / -78 °C
3.2: 4 h / -78 - 20 °C
4.1: thionyl chloride / dichloromethane / 2 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 5 °C
5.2: 3 h / 5 °C
6.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 3 h / 20 °C
7.1: 3 h / 100 °C
8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
9.1: sodium hydroxide / ethanol / 1 h / 20 °C
With
1H-imidazole; N-Bromosuccinimide; n-butyllithium; thionyl chloride; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil; pentane;
DOI:10.1016/j.bmc.2013.11.001
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 5 °C
1.2: 3 h / 5 °C
2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 3 h / 20 °C
3.1: 3 h / 100 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
5.1: sodium hydroxide / ethanol / 1 h / 20 °C
With
palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; sodium hydroxide;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2013.11.001
