8-naphthyridine-1(2H)-carboxamide

Base Information

Chemical Name:8-naphthyridine-1(2H)-carboxamide
CAS No.:1708971-55-4
Molecular Formula:C₂₅H₃₀N₈O₄
Molecular Weight:506.564
Hs Code.:
Mol file:1708971-55-4.mol

Synonyms:

Suppliers and Price of 8-naphthyridine-1(2H)-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
FGF401(Roblitinib) >98%
1 g
$ 2400.00

Crysdot
FGF401 98+%
250mg
$ 1766.00

Crysdot
FGF401 98+%
10mg
$ 168.00

Crysdot
FGF401 98+%
50mg
$ 535.00

ChemScene
Roblitinib 99.33%
10mg
$ 210.00

ChemScene
Roblitinib 99.33%
5mg
$ 130.00

ChemScene
Roblitinib 99.33%
2mg
$ 95.00

ChemScene
Roblitinib 99.33%
100mg
$ 1170.00

ChemScene
Roblitinib 99.33%
50mg
$ 690.00

Cayman Chemical
FGF401
10mg
$ 240.00

Total 23 raw suppliers

Chemical Property of 8-naphthyridine-1(2H)-carboxamide

Chemical Property:

Boiling Point:852.1±65.0 °C(Predicted)
PKA:11.40±0.20(Predicted)
Density:1.39±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

FGF401(Roblitinib) >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description FGF401 is an inhibitor of FGF receptor 4 (FGFR4; IC50 = 1.9 nM). It inhibits proliferation of Huh7 carcinoma cells with an IC50 value of 12 nM. FGF401 induces bile acid synthesis in dogs, increasing plasma and fecal levels of bile acids when administered at a dose of 45 mg/kg per day for four weeks. It also decreases serum cholesterol when administered at doses ranging from 5 to 45 mg/kg per day.

Technology Process of 8-naphthyridine-1(2H)-carboxamide

There total 18 articles about 8-naphthyridine-1(2H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-(dimethoxymethyl)-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1 (2H)-carboxamide

: 1708971-55-4
N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide

Guidance literature:: With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 1708974-11-1
6-amino-4-fluoronicotinonitrile

: 1708971-55-4
N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 15 h / 50 °C

2.1: 1,1'-Carbonyl-di-(1,2,4-triazole) / 2.42 h / 0 - 20 °C

2.2: 17.5 h / 20 °C

3.1: hydrogenchloride; water / tetrahydrofuran / 3 h / 20 °C

With 1,1'-Carbonyl-di-(1,2,4-triazole); hydrogenchloride; water; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl acetamide;

Reference yield:

: 1708974-12-2
4-fluoranyl-5-iodanylpyridin-2-amine

: 1708971-55-4
N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl acetamide / 3 h / 100 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 15 h / 50 °C

3.1: 1,1'-Carbonyl-di-(1,2,4-triazole) / 2.42 h / 0 - 20 °C

3.2: 17.5 h / 20 °C

4.1: hydrogenchloride; water / tetrahydrofuran / 3 h / 20 °C

With 1,1'-Carbonyl-di-(1,2,4-triazole); hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; water; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; N,N-dimethyl acetamide;