2-(Dimethoxymethyl)-1,8-naphthyridine

Base Information

• Chemical Name: 2-(Dimethoxymethyl)-1,8-naphthyridine
• CAS No.: 204452-90-4
• Molecular Formula: C₁₁H₁₂N₂O₂
• Molecular Weight: 204.228
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID10590321
• Wikidata: Q72468044
• Mol file: 204452-90-4.mol

Synonyms:204452-90-4;2-(Dimethoxymethyl)-1,8-naphthyridine;2-Dimethoxymethyl-[1,8]naphthyridine;1,8-Naphthyridine, 2-(dimethoxymethyl)-;2-(dimethoxymethyl)[1,8]naphthyridine;SCHEMBL325226;DTXSID10590321;SVSHWQZULQIOEI-UHFFFAOYSA-N;MFCD06659019;AKOS015851410;AB25892;SS-3813;AM807416;DB-029663;Dimethoxypyridino[3,2-e]pyridin-2-ylmethane;2-(Dimethoxymethyl)-1 pound not8-naphthyridine;2-Dimethoxymethyl-[1,8]naphthyridine, AldrichCPR;A814567

Chemical Property of 2-(Dimethoxymethyl)-1,8-naphthyridine

Chemical Property:

• Vapor Pressure: 0.006mmHg at 25°C
• Melting Point: 79-82°C
• Refractive Index: 1.586
• Boiling Point: 283°Cat760mmHg
• PKA: 3.13±0.30(Predicted)
• Flash Point: 103.8°C
• PSA: 44.24000
• Density: 1.181g/cm³
• LogP: 1.92120
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 204.089877630
• Heavy Atom Count: 15
• Complexity: 197

Purity/Quality:

97% ^*data from raw suppliers

2-(Dimethoxymethyl)-1,8-naphthyridine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(C1=NC2=C(C=CC=N2)C=C1)OC

Technology Process of 2-(Dimethoxymethyl)-1,8-naphthyridine

There total 4 articles about 2-(Dimethoxymethyl)-1,8-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-Aminonicotinaldehyde (7521-41-7) + Pyruvic aldehyde dimethyl acetal (6342-56-9) → 2-(dimethoxymethyl)-1,8-naphthyridine (204452-90-4)

Guidance literature:

With sodium hydroxide; In ethanol; water monomer; at 20 ℃; for 1h;

DOI:10.1021/jo030297u

Reference yield:

2-Aminonicotinaldehyde (7521-41-7) + 2,2-dimethoxypropanal (18218-94-5) → 2-(dimethoxymethyl)-1,8-naphthyridine (204452-90-4)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 20 ℃;

Reference yield:

1,8-naphthyridine-2-carboxaldehyde (64379-45-9) + trimethyl orthoformate (149-73-5) → 2-(dimethoxymethyl)-1,8-naphthyridine (204452-90-4)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; for 24h; Reflux;

upstream raw materials:

2-Aminonicotinaldehyde

Pyruvic aldehyde dimethyl acetal

2,2-dimethoxypropanal

2-methyl-[1,8]naphthyridine

Downstream raw materials:

3(S)-(6-methoxypyridin-3-yl)-3-alanine tert-butyl ester p-toluenesulfonic acid