3,5-diphosphonobenzoic acid

Base Information

• Chemical Name: 3,5-diphosphonobenzoic acid
• CAS No.: 1192028-87-7
• Molecular Formula: C₇H₈O₈P₂
• Molecular Weight: 282.083
• Mol file: 1192028-87-7.mol

Synonyms:

Chemical Property of 3,5-diphosphonobenzoic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-diphosphonobenzoic acid

There total 3 articles about 3,5-diphosphonobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3,5-dibromobenzoate (51329-15-8) → 3,5-diphosphonobenzoic acid (1192028-87-7)

Guidance literature:

Multi-step reaction with 2 steps

1: nickel dibromide / 180 °C / Reflux; Inert atmosphere

2: hydrogenchloride / water / 12 h / Reflux

With hydrogenchloride; nickel dibromide; In water; 1: |Arbuzov Reaction;

DOI:10.1021/acs.inorgchem.6b00954

Reference yield:

methyl 3,5-bis(diethoxyphosphoryl)benzoate → 3,5-diphosphonobenzoic acid (1192028-87-7)

Guidance literature:

With hydrogenchloride; In water; for 12h; Reflux;

DOI:10.1021/acs.inorgchem.6b00954

Reference yield:

3,5-dibromobenzoic acid (618-58-6) → 3,5-diphosphonobenzoic acid (1192028-87-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: thionyl chloride / 5 h / Reflux; Inert atmosphere

1.2: 12 h / Reflux

2.1: nickel dibromide / 180 °C / Reflux; Inert atmosphere

3.1: hydrogenchloride / water / 12 h / Reflux

With hydrogenchloride; thionyl chloride; nickel dibromide; In water; 2.1: |Arbuzov Reaction;

DOI:10.1021/acs.inorgchem.6b00954

upstream raw materials:

3,5-dibromobenzoic acid

methyl 3,5-dibromobenzoate