GSK4028

Base Information

Chemical Name:GSK4028
CAS No.:2079886-19-2
Molecular Formula:C₁₇H₂₁BrN₄O
Molecular Weight:377.284
Hs Code.:

Synonyms:

Suppliers and Price of GSK4028

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of GSK4028

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of GSK4028

There total 17 articles about GSK4028 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₂H₁₈N₂

: 13645-74-4
4,5-dibromo-2-methyl-2H-pyridazin-3-one

: 2079886-19-2,2079896-25-4
4-bromo-2-methyl-5-(((3RS,5RS)-1-methyl-5-phenylpiperidin-3-yl)amino)pyridazin-3(2H)-one

: C₁₇H₂₁BrN₄O

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 120 ℃; for 7h; Microwave irradiation; Sealed tube;
DOI:10.1021/acs.jmedchem.6b01566

Reference yield:

: 361550-43-8
(5-bromo-pyridin-3-yl)-carbamic acid tert-butyl ester

: 2079886-19-2,2079896-25-4
4-bromo-2-methyl-5-(((3RS,5RS)-1-methyl-5-phenylpiperidin-3-yl)amino)pyridazin-3(2H)-one

: C₁₇H₂₁BrN₄O

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene / 1 h / 100 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide / 16 h / 20 °C

3.1: sodium tetrahydroborate / ethanol / 20 h / 20 °C

3.2: 24 h / 60 °C / 37503.8 Torr

4.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 7 h / 120 °C / Microwave irradiation; Sealed tube

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 1.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.jmedchem.6b01566

Reference yield:

: 361550-43-8
(5-bromo-pyridin-3-yl)-carbamic acid tert-butyl ester

: 2079886-19-2,2079896-25-4
GSK4027

: 2079886-19-2,2079896-25-4
GSK4028

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene / 1 h / 100 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide / 16 h / 20 °C

3.1: sodium tetrahydroborate / ethanol / 20 h / 20 °C

3.2: 24 h / 60 °C / 37503.8 Torr

4.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 7 h / 120 °C / Microwave irradiation; Sealed tube

6.1: Chiralpak AD‐H / ethanol; n-heptane / Resolution of racemate

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; n-heptane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 1.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.jmedchem.6b01566