S-1,1-Diphenyl-1,2-propanediol

Base Information

• Chemical Name: S-1,1-Diphenyl-1,2-propanediol
• CAS No.: 126577-48-8
• Molecular Formula: C15H16O2
• Molecular Weight: 228.28600
• Mol file: 126577-48-8.mol

Synonyms:(R)-1,1-Diphenyl-propane-1,2-diol;(R)-1,1-Diphenyl-1,2-propandiol;

Chemical Property of S-1,1-Diphenyl-1,2-propanediol

Chemical Property:

• Boiling Point: 406.6±40.0 °C(Predicted)
• PKA: 13.28±0.29(Predicted)
• PSA: 40.46000
• Density: 1.152±0.06 g/cm3(Predicted)
• LogP: 2.30330

Purity/Quality:

98.5% ^*data from raw suppliers

1,2-Propanediol,1,1-diphenyl-,(2R)- 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of S-1,1-Diphenyl-1,2-propanediol

There total 3 articles about S-1,1-Diphenyl-1,2-propanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-1,1-diphenyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propan-1-ol → (R)-(+)-1,1-diphenyl-1,2-propanediol (126577-48-8)

Guidance literature:

With sodium perborate tetrahydrate; In tetrahydrofuran; water; at 22 ℃; for 2h; Inert atmosphere;

DOI:10.1002/anie.201603465

Reference yield:

benzophenone (119-61-9) → (R)-(+)-1,1-diphenyl-1,2-propanediol (126577-48-8)

Guidance literature:

Multi-step reaction with 2 steps

1: (R)-(-)-(3,5-dioxa-4-phospha-cyclohepta[2,1-a:3,4-a']di-naphthalen-4-yl)dimethylamine; tetrakis(actonitrile)copper(I) hexafluorophosphate; lithium tert-butoxide / tetrahydrofuran / 24 h / 22 °C / Inert atmosphere

2: sodium perborate tetrahydrate / tetrahydrofuran; water / 2 h / 22 °C / Inert atmosphere

With tetrakis(actonitrile)copper(I) hexafluorophosphate; sodium perborate tetrahydrate; (R)-(-)-(3,5-dioxa-4-phospha-cyclohepta[2,1-a:3,4-a']di-naphthalen-4-yl)dimethylamine; lithium tert-butoxide; In tetrahydrofuran; water;

DOI:10.1002/anie.201603465

Reference yield:

→ (R)-(+)-1,1-diphenyl-1,2-propanediol (126577-48-8)

Guidance literature:

(R)-Milchsaeure-α-butylester, Phenylmagnesiumbromid;

DOI:10.1021/ja00746a040

upstream raw materials:

benzophenone

Downstream raw materials:

2-Methyl-1,1-diphenylethylensulfit

Refernces