2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-3-PHENYL-PROPIONIC ACID

Base Information

• Chemical Name: 2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-3-PHENYL-PROPIONIC ACID
• CAS No.: 126727-04-6
• Molecular Formula: C24H21NO4
• Molecular Weight: 387.435
• Mol file: 126727-04-6.mol

Synonyms:α-(9-fluorenylmethyloxycarbonyl)phenylalanine;2-(9-fluorenylmethoxycarbonylamino)-3-phenylpropionic acid;Fmoc-DL-Phe;D,L-Fmoc-Phe-OH;Fmoc-DL-Phe-OH;Fmoc-Phe-OH;

Chemical Property of 2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-3-PHENYL-PROPIONIC ACID

Chemical Property:

• PSA: 75.63000
• LogP: 4.61190
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Fmoc-DL-Phe-OH 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-3-PHENYL-PROPIONIC ACID

There total 6 articles about 2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-3-PHENYL-PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C27H25NO4 → 2-(9-fluorenylmethoxycarbonylamino)-3-phenylpropionic acid (126727-04-6)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); In benzene; at 65 - 70 ℃; for 3h;

DOI:10.1055/S-2008-1072727

Reference yield: 98.0%

(D,L)-Fmoc-Phe-OtBu → 2-(9-fluorenylmethoxycarbonylamino)-3-phenylpropionic acid (126727-04-6)

Guidance literature:

With magnesium iodide; In tetrahydrofuran; at 120 ℃; for 0.25h; chemoselective reaction; Inert atmosphere; Microwave irradiation;

DOI:10.1002/chem.201501799

Reference yield: 92.0%

9-fluorenylmethyl 4,6-dimethoxy-1,3,5-triazinyl carbonate (909114-66-5) + Phenylalanine (150-30-1,25191-15-5,658-69-5,67675-33-6) → 2-(9-fluorenylmethoxycarbonylamino)-3-phenylpropionic acid (126727-04-6)

Guidance literature:

With sodium carbonate; In acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1055/s-2006-942389

upstream raw materials:

9-fluorenylmethyl 4,6-dimethoxy-1,3,5-triazinyl carbonate

Phenylalanine

(fluorenylmethoxy)carbonyl chloride

Downstream raw materials:

2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionic acid 2,4,5-trichloro-phenyl ester