Technology Process of 1-methyl-5-(1-(3,4,5-trimethoxyphenyl)vinyl)-3-vinyl-1H-indole
There total 6 articles about 1-methyl-5-(1-(3,4,5-trimethoxyphenyl)vinyl)-3-vinyl-1H-indole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl-triphenylphosphonium iodide;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
Irradiation;
C20H19NO6;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 24h;
Inert atmosphere;
DOI:10.1021/jm3015603
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: 24 h / -78 - 20 °C / Inert atmosphere
2.1: dipyridinium dichromate / dichloromethane / 24 h / 0 °C / Molecular sieve
3.1: trichlorophosphate / 1 h / 0 °C
3.2: 2 h / 60 °C
4.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 12 h / 20 °C
5.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Irradiation
5.2: 24 h / -78 - 20 °C / Inert atmosphere
With
sodium chlorite; dipyridinium dichromate; n-butyllithium; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; trichlorophosphate;
In
tetrahydrofuran; hexane; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jm3015603
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dipyridinium dichromate / dichloromethane / 24 h / 0 °C / Molecular sieve
2.1: trichlorophosphate / 1 h / 0 °C
2.2: 2 h / 60 °C
3.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 12 h / 20 °C
4.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Irradiation
4.2: 24 h / -78 - 20 °C / Inert atmosphere
With
sodium chlorite; dipyridinium dichromate; n-butyllithium; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; trichlorophosphate;
In
tetrahydrofuran; hexane; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jm3015603
