1427690-81-0Relevant articles and documents
Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4
Lamaa, Diana,Lin, Hsin-Ping,Zig, Lena,Bauvais, Cyril,Bollot, Guillaume,Bignon, Jér?me,Levaique, Helene,Pamlard, Olivier,Dubois, Joelle,Ouaissi, Mehdi,Souce, Martin,Kasselouri, Athena,Saller, Fran?ois,Borgel, Delphine,Jayat-Vignoles, Chantal,Al-Mouhammad, Hazar,Feuillard, Jean,Benihoud, Karim,Alami, Mouad,Hamze, Abdallah
, p. 6574 - 6591 (2018/07/25)
Designing multitarget drugs have raised considerable interest due to their advantages in the treatment of complex diseases such as cancer. Their design constitutes a challenge in antitumor drug discovery. The present study reports a dual inhibition of tub
Endowing indole-based tubulin inhibitors with an anchor for derivatization: Highly potent 3-substituted indolephenstatins and indoleisocombretastatins
álvarez, Raquel,Puebla, Pilar,Díaz, J. Fernando,Bento, Ana C.,García-Navas, Rósula,De La Iglesia-Vicente, Janis,Mollinedo, Faustino,Andreu, José Manuel,Medarde, Manuel,Peláez, Rafael
, p. 2813 - 2827 (2013/06/04)
Colchicine site ligands with indole B rings are potent tubulin polymerization inhibitors. Structural modifications at the indole 3-position of 1-methyl-5-indolyl-based isocombretastatins (1,1-diarylethenes) and phenstatins endowed them with anchors for fu
