UNC-2371A

Base Information

Chemical Name:UNC-2371A
CAS No.:1429882-07-4
Molecular Formula:C₂₉H₄₀N₆O
Molecular Weight:488.676
Hs Code.:
Mol file:1429882-07-4.mol

Synonyms:

Suppliers and Price of UNC-2371A

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
MRX-2843
25mg
$ 545.00

ChemScene
MRX-2843 99.70%
50mg
$ 2040.00

ChemScene
MRX-2843 99.70%
25mg
$ 1320.00

ChemScene
MRX-2843 99.70%
10mg
$ 672.00

ChemScene
MRX-2843 99.70%
1mg
$ 132.00

ChemScene
MRX-2843 99.70%
5mg
$ 396.00

Cayman Chemical
MRX-2843
10mg
$ 273.00

Cayman Chemical
MRX-2843
5mg
$ 146.00

Cayman Chemical
MRX-2843
1mg
$ 39.00

AK Scientific
4-[2-(2-Cyclopropylethylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol
10mg
$ 468.00

Total 18 raw suppliers

Chemical Property of UNC-2371A

Chemical Property:

Melting Point:>137°C (dec.)
Boiling Point:697.3±65.0 °C(Predicted)
PKA:14.63±0.40(Predicted)
Density:1.31±0.1 g/cm3(Predicted)
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)

Purity/Quality:

99%, ^*data from raw suppliers

MRX-2843 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description MRX-2843 is an inhibitor of Mer and FMS-like tyrosine kinase 3 (FLT3; IC50s = 1.3 and 1 nM, respectively). It also inhibits Axl and Tyro3 (IC50s = 15 and 17 nM, respectively). MRX-2843 (10-300 nM) inhibits Mer phosphorylation in MOLM-14 and MV4-11 acute myeloid leukemia (AML) cells and reduces clonal expansion of Kasumi-1 AML cells (IC50 = 143.5 nM). In vivo, MRX-2843 increases survival in NOMO-1 and MOLM-14 AML mouse xenograft models when administered at doses of 65 and 50 mg/kg, respectively.
Uses MRX-2843, is an orally available small-molecule inhibitor of both MERTK and FLT3.

Technology Process of UNC-2371A

There total 5 articles about UNC-2371A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₂₃BrN₄O

: C₁₉H₃₀BNO₂

: 1429882-07-4
trans-4-(2-((2-cyclopropylethyl)amino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexan-1-ol

Guidance literature:: C₁₇H₂₃BrN₄O; C₁₉H₃₀BNO₂; With potassium carbonate; In ethanol; water; for 1h;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; at 40 - 58 ℃; for 20h;

Reference yield:

: C₃₅H₅₄N₆OSi

: 1429882-07-4
trans-4-(2-((2-cyclopropylethyl)amino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexan-1-ol

Guidance literature:: With hydrogenchloride; In methanol; at 20 ℃; for 1h;
DOI:10.1021/jm500749d

Reference yield:

: 1630906-40-9
trans-4-(5-bromo-2-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexan-1-ol

: 1429882-07-4
trans-4-(2-((2-cyclopropylethyl)amino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 85 h / 97 °C

2.1: potassium carbonate / water; ethanol / 1 h

2.2: 20 h / 40 - 58 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In ethanol; water; isopropyl alcohol;