4-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester, 95%

Base Information

• Chemical Name: 4-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester, 95%
• CAS No.: 938043-30-2
• Molecular Formula: C18H29BN2O2
• Molecular Weight: 316.251
• Hs Code.: 2934999090
• Mol file: 938043-30-2.mol

Synonyms:4-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester, 95%;1-Methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine;4-(4-Methylpiperazino)methylphenylboronic acid, pinacol ester;4-(4-METHYL-1-PIPERAZINYLMETHYL)BENZENEBORONIC ACID PINACOL ESTER,95%;4-((4-Methylpiperazin-1-yl)methyl)-phenylboronic acid pinacol ester;1-Methyl-4-[[4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]Methyl]piperazine

Chemical Property of 4-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester, 95%

Chemical Property:

• Melting Point: 61-65°C
• Boiling Point: 412.7±35.0 °C(Predicted)
• PKA: 7.59±0.10(Predicted)
• PSA: 24.94000
• Density: 1.06±0.1 g/cm3(Predicted)
• LogP: 1.60900
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

4-((4-Methylpiperazin-1-yl)methyl)phenylboronicAcidPinacolEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester, 95%

There total 9 articles about 4-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester, 95% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-methyl-piperazine (109-01-3) + 4-bromomethylphenylboronic acid pinacol ester (138500-85-3) → 1-methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine (938043-30-2)

Guidance literature:

With PS-NMM; In tetrahydrofuran; at 150 ℃; for 0.583333h; Microwave irradiation; in air;

DOI:10.1021/co100011g

Reference yield: 96.0%

→ 1-methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine (938043-30-2)

Guidance literature:

Reference yield: 90.0%

4-[(4-methylpiperazin-1-yl)methyl]bromobenzene (368879-17-8) + bis(pinacol)diborane (73183-34-3) → 1-methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine (938043-30-2)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 110 ℃; for 12h; Inert atmosphere;

upstream raw materials:

1-methyl-piperazine

4-bromomethylphenylboronic acid pinacol ester

4-[(4-methylpiperazin-1-yl)methyl]bromobenzene

bis(pinacol)diborane

Downstream raw materials:

(3-{7-[4-(4-methyl-piperazin1-ylmethyl)phenyl]imidazo[1,2-a]pyridin3-yl}-phenyl)(3H-[1,2,3]triazol-4-yl)-amine formate

trans-4-(6-(butylamino)-3-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexanol

trans-4-(2-((2-cyclopropylethyl)amino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexan-1-ol