(5-(2,3,3,4,4,5,5,6,6,7,7,7-dodecafluoro-1-[⁽²⁾H₃]methoxyhept-1-enyl)-1,3-phenylene)dimethanol

Base Information

• Chemical Name: (5-(2,3,3,4,4,5,5,6,6,7,7,7-dodecafluoro-1-[⁽²⁾H₃]methoxyhept-1-enyl)-1,3-phenylene)dimethanol
• CAS No.: 1335496-83-7
• Molecular Formula: C₁₆H₁₂F₁₂O₃
• Molecular Weight: 483.226

Synonyms:

Chemical Property of (5-(2,3,3,4,4,5,5,6,6,7,7,7-dodecafluoro-1-[⁽²⁾H₃]methoxyhept-1-enyl)-1,3-phenylene)dimethanol

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (5-(2,3,3,4,4,5,5,6,6,7,7,7-dodecafluoro-1-[⁽²⁾H₃]methoxyhept-1-enyl)-1,3-phenylene)dimethanol

There total 8 articles about (5-(2,3,3,4,4,5,5,6,6,7,7,7-dodecafluoro-1-[⁽²⁾H₃]methoxyhept-1-enyl)-1,3-phenylene)dimethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3,5-bis((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one (1335496-60-0) → (5-(2,3,3,4,4,5,5,6,6,7,7,7-dodecafluoro-1-[(2)H3]methoxyhept-1-enyl)-1,3-phenylene)dimethanol (1335496-83-7)

Guidance literature:

Multi-step reaction with 6 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol / 16 h / Reflux

2: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.67 h / 0 - 25 °C / Inert atmosphere

3: hydrogen fluoride / water; acetonitrile / 4 h

4: ammonia / diethyl ether / 8 h / -50 °C / Inert atmosphere

5: iodine; triethylamine / methanol / 0.5 h / 25 °C / Inert atmosphere

6: UV-irradiation

With dmap; hydrogen fluoride; hydroxylamine hydrochloride; ammonia; iodine; sodium acetate; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; ethanol; dichloromethane; water; acetonitrile;

DOI:10.1039/c1ob05748k

Reference yield:

1-(3,5-bis((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one oxime (1335496-61-1) → (5-(2,3,3,4,4,5,5,6,6,7,7,7-dodecafluoro-1-[(2)H3]methoxyhept-1-enyl)-1,3-phenylene)dimethanol (1335496-83-7)

Guidance literature:

Multi-step reaction with 5 steps

1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.67 h / 0 - 25 °C / Inert atmosphere

2: hydrogen fluoride / water; acetonitrile / 4 h

3: ammonia / diethyl ether / 8 h / -50 °C / Inert atmosphere

4: iodine; triethylamine / methanol / 0.5 h / 25 °C / Inert atmosphere

5: UV-irradiation

With dmap; hydrogen fluoride; ammonia; iodine; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; dichloromethane; water; acetonitrile;

DOI:10.1039/c1ob05748k

Reference yield:

1-(3,5-bis((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one O-(p-tosyl)oxime (1335496-64-4) → (5-(2,3,3,4,4,5,5,6,6,7,7,7-dodecafluoro-1-[(2)H3]methoxyhept-1-enyl)-1,3-phenylene)dimethanol (1335496-83-7)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogen fluoride / water; acetonitrile / 4 h

2: ammonia / diethyl ether / 8 h / -50 °C / Inert atmosphere

3: iodine; triethylamine / methanol / 0.5 h / 25 °C / Inert atmosphere

4: UV-irradiation

With hydrogen fluoride; ammonia; iodine; triethylamine; In methanol; diethyl ether; water; acetonitrile;

DOI:10.1039/c1ob05748k

upstream raw materials:

1-(3,5-bis((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one

1-(3,5-bis((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one oxime

1-(3,5-bis((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one O-(p-tosyl)oxime

d⁽⁴⁾-methanol

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