C₃₆H₄₆FN₇O₆

Base Information

Chemical Name:C₃₆H₄₆FN₇O₆
CAS No.:1332639-73-2
Molecular Formula:C₃₆H₄₆FN₇O₆
Molecular Weight:691.803
Hs Code.:

C<sub>36</sub>H<sub>46</sub>FN<sub>7</sub>O<sub>6</sub>

Synonyms:

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Chemical Property of C₃₆H₄₆FN₇O₆

Chemical Property:

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Technology Process of C₃₆H₄₆FN₇O₆

There total 29 articles about C₃₆H₄₆FN₇O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 187039-57-2,335280-19-8
(2S,3S)-1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid

: 1332639-73-2
C₃₆H₄₆FN₇O₆

Guidance literature:: Multi-step reaction with 22 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 90 °C

2.1: 1H-imidazole / dichloromethane / 6 h / 0 - 20 °C

3.1: lithium borohydride / tetrahydrofuran / 3 h / 0 - 20 °C

4.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2 h / 0 - 20 °C

5.1: triethylamine / 12 h

6.1: thionyl chloride / dichloromethane / 1 h / -78 °C

6.2: 1 h / -78 °C

7.1: / acetonitrile / 16 h / 20 °C

8.1: hydrogen / ethanol / 1.5 h / 2585.81 Torr

9.1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 - 45 °C

11.1: dmap / dichloromethane / 3 h / 0 °C

12.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

13.1: sodium periodate / ruthenium(III) trichloride hydrate / 1-methyl-pyrrolidin-2-one; tetrachloromethane; acetonitrile; water / 3.83 h

14.1: ethyl acetate; diethyl ether

15.1: lithium borohydride / tetrahydrofuran / 3 h / 0 °C

16.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

17.1: sodium azide / N,N-dimethyl-formamide / 2 h / 80 °C

18.1: copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate / ethanol; water; tert-butyl alcohol

19.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol

20.1: HATU / 1-methyl-pyrrolidin-2-one

21.1: trifluoroacetic acid / dichloromethane

22.1: HATU / 1-methyl-pyrrolidin-2-one

With 1H-imidazole; dmap; sodium periodate; lithium borohydride; thionyl chloride; sodium azide; copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; tetrabutyl ammonium fluoride; hydrogen; sulfur trioxide pyridine complex; sodium hydride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; ruthenium(III) trichloride hydrate; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

Reference yield:

: 184046-78-4
(2S,3S)-1-tert-butyl-2-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate

: 1332639-73-2
C₃₆H₄₆FN₇O₆

Guidance literature:: Multi-step reaction with 21 steps

1.1: 1H-imidazole / dichloromethane / 6 h / 0 - 20 °C

2.1: lithium borohydride / tetrahydrofuran / 3 h / 0 - 20 °C

3.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2 h / 0 - 20 °C

4.1: triethylamine / 12 h

5.1: thionyl chloride / dichloromethane / 1 h / -78 °C

5.2: 1 h / -78 °C

6.1: / acetonitrile / 16 h / 20 °C

7.1: hydrogen / ethanol / 1.5 h / 2585.81 Torr

8.1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 - 45 °C

10.1: dmap / dichloromethane / 3 h / 0 °C

11.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

12.1: sodium periodate / ruthenium(III) trichloride hydrate / 1-methyl-pyrrolidin-2-one; tetrachloromethane; acetonitrile; water / 3.83 h

13.1: ethyl acetate; diethyl ether

14.1: lithium borohydride / tetrahydrofuran / 3 h / 0 °C

15.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

16.1: sodium azide / N,N-dimethyl-formamide / 2 h / 80 °C

17.1: copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate / ethanol; water; tert-butyl alcohol

18.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol

19.1: HATU / 1-methyl-pyrrolidin-2-one

20.1: trifluoroacetic acid / dichloromethane

21.1: HATU / 1-methyl-pyrrolidin-2-one

With 1H-imidazole; dmap; sodium periodate; lithium borohydride; thionyl chloride; sodium azide; copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; tetrabutyl ammonium fluoride; hydrogen; sulfur trioxide pyridine complex; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; ruthenium(III) trichloride hydrate; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

Reference yield:

: 156129-73-6
tert-butyl (2R,3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-2-(hydroxymethyl)pyrrolidine-1-carboxylate

: 1332639-73-2
C₃₆H₄₆FN₇O₆

Guidance literature:: Multi-step reaction with 19 steps

1.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2 h / 0 - 20 °C

2.1: triethylamine / 12 h

3.1: thionyl chloride / dichloromethane / 1 h / -78 °C

3.2: 1 h / -78 °C

4.1: / acetonitrile / 16 h / 20 °C

5.1: hydrogen / ethanol / 1.5 h / 2585.81 Torr

6.1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 - 45 °C

8.1: dmap / dichloromethane / 3 h / 0 °C

9.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

10.1: sodium periodate / ruthenium(III) trichloride hydrate / 1-methyl-pyrrolidin-2-one; tetrachloromethane; acetonitrile; water / 3.83 h

11.1: ethyl acetate; diethyl ether

12.1: lithium borohydride / tetrahydrofuran / 3 h / 0 °C

13.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

14.1: sodium azide / N,N-dimethyl-formamide / 2 h / 80 °C

15.1: copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate / ethanol; water; tert-butyl alcohol

16.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol

17.1: HATU / 1-methyl-pyrrolidin-2-one

18.1: trifluoroacetic acid / dichloromethane

19.1: HATU / 1-methyl-pyrrolidin-2-one

With dmap; sodium periodate; lithium borohydride; thionyl chloride; sodium azide; copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; tetrabutyl ammonium fluoride; hydrogen; sulfur trioxide pyridine complex; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; ruthenium(III) trichloride hydrate; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;