N-(1-((1S)-3-(dimethylamino)-1-phenylpropyl)-1H-pyrazol-4-yl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide

Base Information

• Chemical Name: N-(1-((1S)-3-(dimethylamino)-1-phenylpropyl)-1H-pyrazol-4-yl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide
• CAS No.: 1557232-32-2
• Molecular Formula: C₂₄H₃₂N₆O
• Molecular Weight: 420.558
• Mol file: 1557232-32-2.mol

Synonyms:

Chemical Property of N-(1-((1S)-3-(dimethylamino)-1-phenylpropyl)-1H-pyrazol-4-yl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1-((1S)-3-(dimethylamino)-1-phenylpropyl)-1H-pyrazol-4-yl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide

There total 8 articles about N-(1-((1S)-3-(dimethylamino)-1-phenylpropyl)-1H-pyrazol-4-yl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C30H46N6O2Si (1557248-88-0) → N-(1-((1R)-3-(dimethylamino)-1-phenylpropyl)-1H-pyrazol-4-yl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide (1557232-30-0) + N-(1-((1S)-3-(dimethylamino)-1-phenylpropyl)-1H-pyrazol-4-yl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide (1557232-32-2)

Guidance literature:

C₃₀H₄₆N₆O₂Si; With hydrogenchloride; In 1,4-dioxane; at 60 ℃; for 1h;

With sodium hydroxide; In ethanol; water; at 20 ℃; for 1h;

DOI:10.1021/jm500550e

Reference yield:

C12H20N2O3 → N-(1-((1R)-3-(dimethylamino)-1-phenylpropyl)-1H-pyrazol-4-yl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide (1557232-30-0) + N-(1-((1S)-3-(dimethylamino)-1-phenylpropyl)-1H-pyrazol-4-yl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide (1557232-32-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: pyridine; trichlorophosphate / 20 °C

1.2: 110 °C

2.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

2.2: 0 - 20 °C

3.1: lithium hydroxide monohydrate / acetonitrile; water; tetrahydrofuran / 20 °C

4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 1 h / 60 °C

5.2: 1 h / 20 °C

With pyridine; hydrogenchloride; lithium hydroxide monohydrate; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm500550e

Reference yield:

C18H32N2O3Si → N-(1-((1R)-3-(dimethylamino)-1-phenylpropyl)-1H-pyrazol-4-yl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide (1557232-30-0) + N-(1-((1S)-3-(dimethylamino)-1-phenylpropyl)-1H-pyrazol-4-yl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide (1557232-32-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium hydroxide monohydrate / acetonitrile; water; tetrahydrofuran / 20 °C

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 1 h / 60 °C

3.2: 1 h / 20 °C

With hydrogenchloride; lithium hydroxide monohydrate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm500550e

upstream raw materials:

ethyl 6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate

C₃₀H₄₆N₆O₂Si

1-(3-(dimethylamino)-1-phenylpropyl)-1H-pyrazol-4-amine

6,6-dimethyl-1-((2-(trimethylsilyl)ethoxy)methyl)-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid