ethyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-4,4-difluoro-N2-[(4-nitrophenyl)sulfonyl]-L-lysinate

Base Information

Chemical Name:ethyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-4,4-difluoro-N2-[(4-nitrophenyl)sulfonyl]-L-lysinate
CAS No.:1374138-44-9
Molecular Formula:C₃₁H₃₄F₂N₄O₉S
Molecular Weight:676.695
Hs Code.:

Synonyms:

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Chemical Property of ethyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-4,4-difluoro-N2-[(4-nitrophenyl)sulfonyl]-L-lysinate

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Technology Process of ethyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-4,4-difluoro-N2-[(4-nitrophenyl)sulfonyl]-L-lysinate

There total 8 articles about ethyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-4,4-difluoro-N2-[(4-nitrophenyl)sulfonyl]-L-lysinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 1374138-44-9
ethyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-4,4-difluoro-N2-[(4-nitrophenyl)sulfonyl]-L-lysinate

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / dmap / acetonitrile / 20 °C

2.1: dmap / acetonitrile / 48 h / 20 °C

3.1: diisobutylaluminium hydride / toluene; diethyl ether / 0.75 h / -70 °C

3.2: 1.5 h / 20 °C

4.1: N-fluorobis(benzenesulfon)imide; rac-Pro-OH / isopropyl alcohol; tetrahydrofuran / 24 h / 20 °C

4.2: 0 - 20 °C

4.3: 3 h / 0 - 20 °C

5.1: water; sodium tetrahydroborate / tetrahydrofuran / 4 h / 20 °C

6.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 20 h / 1810.07 Torr

7.1: sodium hydrogencarbonate / water; tetrahydrofuran / 0 - 20 °C

8.1: trifluoroacetic acid; methoxybenzene / dichloromethane / 2 h / 0 - 20 °C

9.1: pyridine / dmap / 85 °C

With pyridine; sodium tetrahydroborate; water; hydrogen; diisobutylaluminium hydride; sodium hydrogencarbonate; methoxybenzene; N-fluorobis(benzenesulfon)imide; triethylamine; trifluoroacetic acid; rac-Pro-OH; dmap; palladium 10% on activated carbon; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; isopropyl alcohol; toluene; acetonitrile;

Reference yield:

: 1374138-35-8
diethyl N,N-bis(tert-butoxycarbonyl)-L-glutamate

: 1374138-44-9
ethyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-4,4-difluoro-N2-[(4-nitrophenyl)sulfonyl]-L-lysinate

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisobutylaluminium hydride / toluene; diethyl ether / 0.75 h / -70 °C

1.2: 1.5 h / 20 °C

2.1: N-fluorobis(benzenesulfon)imide; rac-Pro-OH / isopropyl alcohol; tetrahydrofuran / 24 h / 20 °C

2.2: 0 - 20 °C

2.3: 3 h / 0 - 20 °C

3.1: water; sodium tetrahydroborate / tetrahydrofuran / 4 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 20 h / 1810.07 Torr

5.1: sodium hydrogencarbonate / water; tetrahydrofuran / 0 - 20 °C

6.1: trifluoroacetic acid; methoxybenzene / dichloromethane / 2 h / 0 - 20 °C

7.1: pyridine / dmap / 85 °C

With pyridine; sodium tetrahydroborate; water; hydrogen; diisobutylaluminium hydride; sodium hydrogencarbonate; methoxybenzene; N-fluorobis(benzenesulfon)imide; trifluoroacetic acid; rac-Pro-OH; dmap; palladium 10% on activated carbon; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; isopropyl alcohol; toluene;

Reference yield:

: 130696-54-7
diethyl (tert-butoxycarbonyl)-L-glutamate

: 1374138-44-9
ethyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-4,4-difluoro-N2-[(4-nitrophenyl)sulfonyl]-L-lysinate

Guidance literature:: Multi-step reaction with 8 steps

1.1: dmap / acetonitrile / 48 h / 20 °C

2.1: diisobutylaluminium hydride / toluene; diethyl ether / 0.75 h / -70 °C

2.2: 1.5 h / 20 °C

3.1: N-fluorobis(benzenesulfon)imide; rac-Pro-OH / isopropyl alcohol; tetrahydrofuran / 24 h / 20 °C

3.2: 0 - 20 °C

3.3: 3 h / 0 - 20 °C

4.1: water; sodium tetrahydroborate / tetrahydrofuran / 4 h / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 20 h / 1810.07 Torr

6.1: sodium hydrogencarbonate / water; tetrahydrofuran / 0 - 20 °C

7.1: trifluoroacetic acid; methoxybenzene / dichloromethane / 2 h / 0 - 20 °C

8.1: pyridine / dmap / 85 °C

With pyridine; sodium tetrahydroborate; water; hydrogen; diisobutylaluminium hydride; sodium hydrogencarbonate; methoxybenzene; N-fluorobis(benzenesulfon)imide; trifluoroacetic acid; rac-Pro-OH; dmap; palladium 10% on activated carbon; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; isopropyl alcohol; toluene; acetonitrile;