Iva-PheΨPhe-Sta-Ala-Sta-NHCH2Ph

Base Information

• Chemical Name: Iva-PheΨPhe-Sta-Ala-Sta-NHCH2Ph
• CAS No.: 118388-48-0
• Molecular Formula: C₄₉H₇₁N₅O₈S
• Molecular Weight: 890.197
• Mol file: 118388-48-0.mol

Synonyms:

Chemical Property of Iva-PheΨPhe-Sta-Ala-Sta-NHCH2Ph

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Iva-PheΨPhe-Sta-Ala-Sta-NHCH2Ph

There total 6 articles about Iva-PheΨPhe-Sta-Ala-Sta-NHCH2Ph which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[(S)-2-(3-Methyl-butyrylamino)-3-phenyl-propane-1-sulfinyl]-3-phenyl-propionic acid (118387-89-6,124266-99-5,124267-05-6) + Sta-Ala-Sta-NHCH2Ph (118387-69-2) → Iva-PheΨPhe-Sta-Ala-Sta-NHCH2Ph (118388-48-0,124339-11-3,124339-38-4)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1021/jm00164a058

Reference yield:

(2S)-2-benzylazacyclopropane (73058-30-7) → Iva-PheΨPhe-Sta-Ala-Sta-NHCH2Ph (118388-48-0,124339-11-3,124339-38-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 100 percent / H₂S / ethanol / from -78 deg C to room temp.

2: 82 percent / liq. NH₃ / overnight

3: 59 percent / Et₃N / CH₂Cl₂ / 0 °C

4: 57 percent / trifluoroacetic acid

5: 70.6 percent / 0.5 M NaIO₄ / methanol / 2 h / Ambient temperature

6: HOBT/DCC, Et₃N / dimethylformamide; CH₂Cl₂ / 0 - 20 °C

With sodium periodate; hydrogen sulfide; ammonia; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00164a058

Reference yield:

(S)-2-amino-3-phenyl-1-propanethiol (116264-32-5) → Iva-PheΨPhe-Sta-Ala-Sta-NHCH2Ph (118388-48-0,124339-11-3,124339-38-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 82 percent / liq. NH₃ / overnight

2: 59 percent / Et₃N / CH₂Cl₂ / 0 °C

3: 57 percent / trifluoroacetic acid

4: 70.6 percent / 0.5 M NaIO₄ / methanol / 2 h / Ambient temperature

5: HOBT/DCC, Et₃N / dimethylformamide; CH₂Cl₂ / 0 - 20 °C

With sodium periodate; ammonia; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00164a058

upstream raw materials:

2-[(S)-2-(3-Methyl-butyrylamino)-3-phenyl-propane-1-sulfinyl]-3-phenyl-propionic acid

Sta-Ala-Sta-NHCH₂Ph

(2S)-2-benzylazacyclopropane

(S)-2-amino-3-phenyl-1-propanethiol