C₂₁H₁₄N₄OS

Base Information

• Chemical Name: C₂₁H₁₄N₄OS
• CAS No.: 1417334-86-1
• Molecular Formula: C₂₁H₁₄N₄OS
• Molecular Weight: 370.434
• Mol file: 1417334-86-1.mol

Synonyms:

Chemical Property of C₂₁H₁₄N₄OS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₁₄N₄OS

There total 4 articles about C₂₁H₁₄N₄OS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isoniazid (54-85-3,7640-37-1) → C21H14N4OS (1417334-86-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / ethanol / Inert atmosphere; Reflux

2: sodium hydroxide / N,N-dimethyl-formamide / 5 h / 20 °C

With triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2012.06.006

Reference yield:

p-(p-tolyl)benzonitrile (50670-50-3) → C21H14N4OS (1417334-86-1)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / toluene; tetrachloromethane / 80 °C / Inert atmosphere

2: sodium hydroxide / N,N-dimethyl-formamide / 5 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydroxide; In tetrachloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.ejmech.2012.06.006

Reference yield:

4-bromobenzenecarbonitrile (623-00-7) → C21H14N4OS (1417334-86-1)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene; water / 80 °C / Inert atmosphere

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / toluene; tetrachloromethane / 80 °C / Inert atmosphere

3: sodium hydroxide / N,N-dimethyl-formamide / 5 h / 20 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); sodium carbonate; sodium hydroxide; In tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.ejmech.2012.06.006

upstream raw materials:

isoniazid

p-(p-tolyl)benzonitrile

4-bromobenzenecarbonitrile

4-methylphenylboronic acid