Hydroxy-(4-phenoxy-phenyl)-acetonitrile

Base Information

• Chemical Name: Hydroxy-(4-phenoxy-phenyl)-acetonitrile
• CAS No.: 177793-92-9
• Molecular Formula: C₁₄H₁₁NO₂
• Molecular Weight: 225.247
• Mol file: 177793-92-9.mol

Synonyms:

Chemical Property of Hydroxy-(4-phenoxy-phenyl)-acetonitrile

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Hydroxy-(4-phenoxy-phenyl)-acetonitrile

There total 2 articles about Hydroxy-(4-phenoxy-phenyl)-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-phenoxyphenyl)-2-[(trimethylsilyl)oxy]acetonitrile (740817-70-3) → Hydroxy-(4-phenoxy-phenyl)-acetonitrile (177793-92-9)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran;

DOI:10.1039/C39890001391

Reference yield:

4-phenoxy benzaldehyde (67-36-7) → Hydroxy-(4-phenoxy-phenyl)-acetonitrile (177793-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: ZnI₂

2: aq. HCl / tetrahydrofuran

With hydrogenchloride; zinc(II) iodide; In tetrahydrofuran;

DOI:10.1039/C39890001391

Reference yield:

acetic anhydride (108-24-7) + Hydroxy-(4-phenoxy-phenyl)-acetonitrile (177793-92-9) → Acetic acid (R)-cyano-(4-phenoxy-phenyl)-methyl ester

Guidance literature:

With pyridine; Yield given;

DOI:10.1039/C39890001391

upstream raw materials:

2-(4-phenoxyphenyl)-2-[(trimethylsilyl)oxy]acetonitrile

4-phenoxy benzaldehyde