740817-70-3

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 67-36-7 4-phenoxy benzaldehyde 

Downstream Products

• 799279-31-5 2-(3-chlorophenyl)-1-(4-phenoxyphenyl)-2-hydroxyethan-1-one 
• 1443126-21-3 N-cyclohexyl-2-oxo-5-(4-phenoxyphenyl)oxazolidine-3-carboxamide 
• 153285-74-6 2-amino-1-(4-phenoxyphenyl)ethanol 
• 220531-54-4 Bromo-(4-phenoxy-phenyl)-acetic acid ethyl ester 
• 177793-92-9 Hydroxy-(4-phenoxy-phenyl)-acetonitrile 
• 114373-54-5 Hydroxy-(4-phenoxy-phenyl)-acetic acid ethyl ester 

Relevant academic research and scientific papers

Two scandium coordination polymers: Rapid synthesis and catalytic properties

Two scandium coordination polymers (Sc-CPs), [Sc(L1)2(DMF)] (DMF = N,N′-dimethyl formamide, H2L1 = pyrazine-2,3-dicarboxylic acid) (1) and [Sc(L2)(C2O4)0.5(H2/su

Tunable morphology and the changeable catalytic property of layered scandium coordination polymer

Sc-CP 1, 1A, 1B and 1C with controllable morphologies were successfully synthesized by the conventional hydrothermal method and microwave (MW) assisted hydrothermal method. 1 was macroscopic, 1A was nano sized, while 1B and 1C were micron sized. Sc-CP 1 s

Hydroboration, Cyanosilylation, and Sequential Cyanosilylation and Hydroboration of Carbonyl Compounds in the Presence of a TiIV Amido Complex as an Efficient Catalyst

Catalytic hydroboration and cyanosilylation of a wide range of aldehydes and ketones, with pinacolborane (4,4,5,5-tetramethyl-1,3,2-dioxaborolane) and trimethylsilyl cyanide, respectively, in the presence of titanium(IV) complexes [κ2-{(C5

Porous barium-organic frameworks with highly efficient catalytic capacity and fluorescence sensing ability

The current study describes the first barium-organic framework with permanent porosity, efficient catalytic capacity, and highly selective luminescence sensing of DMSO molecules and metal ions. Single-crystal-to-single-crystal transformations (from comple

(4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL)

Inhibitors of the enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), the principle enzymes involved in the degradation of endogenous cannabinoids like anandamide and 2- arachidonoylglycerol, have potential utility in the treatment of several disorders including pain, inflammation and anxiety. In the present study, the effectivity and selectivity of eight known FAAH and MAGL inhibitors for inhibition of the appropriate enzyme were measured applying in vitro assays, which work under comparable conditions. Because many of the known FAAH and MAGL inhibitors simply consist of a lipophilic scaffold to which a heterocyclic system is bound, furthermore, different heterocyclic structures were evaluated for their contribution to enzyme inhibition by attaching them to the same lipophilic backbone, namely 4-phenoxybenzene. One of the most active compound synthesized during this investigation was N,N-dimethyl-5-(4-phenoxyphenyl)-2H- tetrazole-2-carboxamide (16) (IC50 FAAH: 0.012 μM; IC50 MAGL: 0.028 μM). This inhibitor was systematically modified in the lipophilic 4-phenoxyphenyl region. Structure-activity relationship studies revealed that the inhibitory potency against FAAH and MAGL, respectively, could still be increased by replacement of the phenoxy residue of 16 by 3-chlorophenoxy (45) or pyrrol-1-yl groups (49). Finally, the tetrazolecarboxamide 16 and some related compounds were tested for metabolic stability with rat liver S9 fractions showing that these kind of FAAH/MAGL inhibitors are readily inactivated by cleavage of the bond between the tetrazole ring and its carboxamide substituent.

A dream combination for catalysis: Highly reactive and recyclable scandium(iii) triflate-catalyzed cyanosilylations of carbonyl compounds in an ionic liquid

The catalytic activity of lanthanide triflates, particularly scandium triflate, increased dramatically in [bmim][SbF6], allowing the cyanosilylation of a variety of aldehydes and ketones with a turnover frequency up to 48000 mol h-1 and a total turnover number of 100000.

Size-selective Lewis acid catalysis in a microporous metal-organic framework with exposed Mn2+ coordination sites

Treatment of selected aldehydes and ketones with cyanotrimethylsilane in the presence of the microporous metal-organic framework Mn3[(Mn4Cl)3BTT8(CH3OH)10]2 (1, H3BTT = 1,3,5-ben

Niobium fluoride (NbF5): A highly efficient catalyst for solvent-free cyanosilylation of aldehydes

An efficient method for the addition of trimethylsilylcyanide (TMSCN) to aldehydes using dispersed NbF5 as the catalyst is described. Cyano transfer from TMSCN to aldehydes occurs within 10 minutes at room temperature in the presence of 0.5 mol

N-methylmorpholine N-oxide: A rare nonmetallic catalyst for the most efficient silylcyanation of aldehydes

An efficient method of addition of trimethylsilyl cyanide (TMSCN) to aldehydes by employing N-methylmorpholine N-oxide (NMO) alone as the catalyst has been described. Most of aromatic, aliphatic, cyclic, and heterocyclic aldehydes have been converted into

Synthesis and antibacterial activity of novel and potent DNA gyrase inhibitors with azole ring

The pyrazole, oxazole and imidazole derivatives synthesized in this study exhibited potent antibacterial activity against multidrug resistant Gram-positive bacteria with minimal inhibitory concentration values equivalent to those against susceptible strains. The 4-piperidyl moiety and the pyrazole ring in 1-(3-chlorophenyl)-5-(4-phenoxyphenyl)-3-(4-piperidyl)pyrazole 2, which has previously shown improved DNA gyrase inhibition and target-related antibacterial activity, were transformed to other groups and the in vitro antibacterial activity of the synthesized compounds was evaluated. The selected pyrazole, oxazole and imidazole derivatives showed moderate inhibition against DNA gyrase and topoisomerase IV with similar IC50 values (IC 50 = 9.4-25 μg/mL). In addition, many of the pyrazole, oxazole a1nd imidazole derivatives synthesized in this study exhibited potent antibacterial activity against quinolone-resistant clinical isolates and coumarin-resistant laboratory isolates of Gram-positive bacteria with minimal inhibitory concentration values equivalent to those against susceptible strains.