C₄₉H₆₆N₆O₁₂

Base Information

• Chemical Name: C₄₉H₆₆N₆O₁₂
• CAS No.: 1584664-44-7
• Molecular Formula: C₄₉H₆₆N₆O₁₂
• Molecular Weight: 931.096
• Mol file: 1584664-44-7.mol

Synonyms:

Chemical Property of C₄₉H₆₆N₆O₁₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₉H₆₆N₆O₁₂

There total 17 articles about C₄₉H₆₆N₆O₁₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C24H36N4O7 (1201179-81-8) + C25H32N2O6*C2HF3O2 (1584664-46-9) → C49H66N6O12 (1584664-44-7)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 28h; Inert atmosphere;

DOI:10.1016/j.tetasy.2014.01.004

Reference yield:

C15H32O3Si (872369-20-5) → C49H66N6O12 (1584664-44-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 3 h / 20 °C / Inert atmosphere

2: pyridine hydrogenfluoride / tetrahydrofuran / 24 h / 0 - 20 °C / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 8 h / 20 °C / Inert atmosphere

4: dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / dichloromethane / 28 h / 0 - 20 °C / Inert atmosphere

With dmap; benzotriazol-1-ol; pyridine hydrogenfluoride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tetasy.2014.01.004

Reference yield:

N-(Benzyloxycarbonyl)glycine (1138-80-3) → C49H66N6O12 (1584664-44-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: benzotriazol-1-ol / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: water; lithium hydroxide / tetrahydrofuran / 0 °C / Inert atmosphere

3.1: benzotriazol-1-ol / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

3.2: 0.33 h / Inert atmosphere

3.3: 20 °C / Inert atmosphere

4.1: water; lithium hydroxide / tetrahydrofuran / Inert atmosphere; Cooling

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / dichloromethane / 28 h / 0 - 20 °C / Inert atmosphere

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tetasy.2014.01.004

upstream raw materials:

C₁₅H₃₂O₃Si

N-(Benzyloxycarbonyl)glycine

(2R,3S)-1-((S)-4-benzyl-2-thioxothiazolidin-3-yl)-5-(benzyloxy)-3-hydroxy-2-methylpentan-1-one

C₂₄H₃₆N₄O₇

Refernces