2,2,2-Trifluoro-N-(5-{2-[1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetylamino}-pentyl)-acetamide

Base Information

Chemical Name:2,2,2-Trifluoro-N-(5-{2-[1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetylamino}-pentyl)-acetamide
CAS No.:208758-78-5
Molecular Formula:C₁₈H₂₅F₃N₄O₇
Molecular Weight:466.414
Hs Code.:

2,2,2-Trifluoro-N-(5-{2-[1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetylamino}-pentyl)-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,2,2-Trifluoro-N-(5-{2-[1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetylamino}-pentyl)-acetamide

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 2,2,2-Trifluoro-N-(5-{2-[1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetylamino}-pentyl)-acetamide

There total 1 articles about 2,2,2-Trifluoro-N-(5-{2-[1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetylamino}-pentyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 383-63-1
ethyl trifluoroacetate,

: N-(5-Amino-pentyl)-2-[1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetamide

: 208758-78-5
2,2,2-Trifluoro-N-(5-{2-[1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetylamino}-pentyl)-acetamide

Guidance literature:: With dmap; In methanol; Yield given; Ambient temperature;
DOI:10.1080/07328319808003463

Reference yield:

: 208758-78-5
2,2,2-Trifluoro-N-(5-{2-[1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetylamino}-pentyl)-acetamide

: 208758-87-6
N-[5-(Acridin-9-ylamino)-pentyl]-2-(1-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: conc. aq. NH₃ / 1.5 h / Ambient temperature

2: phenol / 3.5 h / 80 °C

3: 43.2 percent / DMAP / pyridine / Ambient temperature

With dmap; ammonium hydroxide; phenol; In pyridine;
DOI:10.1080/07328319808003463

Reference yield:

: 208758-78-5
2,2,2-Trifluoro-N-(5-{2-[1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetylamino}-pentyl)-acetamide

: Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(5-{[5-(acridin-9-ylamino)-pentylcarbamoyl]-methyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: conc. aq. NH₃ / 1.5 h / Ambient temperature

2: phenol / 3.5 h / 80 °C

3: 43.2 percent / DMAP / pyridine / Ambient temperature

4: 50.8 percent / iPr₂NEt / CH₂Cl₂ / 1 h / Ambient temperature

With dmap; ammonium hydroxide; N-ethyl-N,N-diisopropylamine; phenol; In pyridine; dichloromethane;
DOI:10.1080/07328319808003463