3-[(2S,8R,9R)-8-({[(4-fluorophenyl)methyl](methyl)amino}methyl)-11-[(2S)-1-hydroxypropan-2-yl]-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxaazacyclotetradecin-14-yl]-1-phenylurea

Base Information

Chemical Name:3-[(2S,8R,9R)-8-({[(4-fluorophenyl)methyl](methyl)amino}methyl)-11-[(2S)-1-hydroxypropan-2-yl]-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxaazacyclotetradecin-14-yl]-1-phenylurea
CAS No.:1353557-43-3
Molecular Formula:C₃₆H₄₇FN₄O₅
Molecular Weight:634.791
Hs Code.:

3-[(2S,8R,9R)-8-({[(4-fluorophenyl)methyl](methyl)amino}methyl)-11-[(2S)-1-hydroxypropan-2-yl]-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxaazacyclotetradecin-14-yl]-1-phenylurea

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Chemical Property of 3-[(2S,8R,9R)-8-({[(4-fluorophenyl)methyl](methyl)amino}methyl)-11-[(2S)-1-hydroxypropan-2-yl]-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxaazacyclotetradecin-14-yl]-1-phenylurea

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Technology Process of 3-[(2S,8R,9R)-8-({[(4-fluorophenyl)methyl](methyl)amino}methyl)-11-[(2S)-1-hydroxypropan-2-yl]-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxaazacyclotetradecin-14-yl]-1-phenylurea

There total 5 articles about 3-[(2S,8R,9R)-8-({[(4-fluorophenyl)methyl](methyl)amino}methyl)-11-[(2S)-1-hydroxypropan-2-yl]-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxaazacyclotetradecin-14-yl]-1-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1255214-08-4
allyl (((2S,8R,9R)-14-((((9H-fIuoren-9-yl)methoxy)carbonyl)amino)-11-((S)-1-hydroxypropan-2-yl)-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-8-yl)methyl)(methyl)carbamate

: 1353557-43-3
3-[(2S,8R,9R)-8-({[(4-fluorophenyl)methyl](methyl)amino}methyl)-11-[(2S)-1-hydroxypropan-2-yl]-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxaazacyclotetradecin-14-yl]-1-phenylurea

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / dichloromethane / 4 h / 20 °C / Inert atmosphere

2.1: piperidine / N,N-dimethyl-formamide / 0.67 h / 20 °C / Inert atmosphere

2.2: 3 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid / dichloromethane / 1 h / Inert atmosphere

4.1: magnesium sulfate / dichloromethane / 1 h / Inert atmosphere

4.2: 4 h / 20 °C / Inert atmosphere

5.1: methanol; potassium carbonate / 15 h / 20 °C / Inert atmosphere

With piperidine; pyridine; methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; magnesium sulfate; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml200244k

Reference yield:

: 1353557-61-5
(S)-2-((2S,8R,9R)-8-((((allyloxy)carbonyl)(methyl)amino)methyl)-2,9-dimethyl-12-oxo-14-(3-phenylureudo)-3,4,5,6,9,10-hexahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate

: 1353557-43-3
3-[(2S,8R,9R)-8-({[(4-fluorophenyl)methyl](methyl)amino}methyl)-11-[(2S)-1-hydroxypropan-2-yl]-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxaazacyclotetradecin-14-yl]-1-phenylurea

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid / dichloromethane / 1 h / Inert atmosphere

2.1: magnesium sulfate / dichloromethane / 1 h / Inert atmosphere

2.2: 4 h / 20 °C / Inert atmosphere

3.1: methanol; potassium carbonate / 15 h / 20 °C / Inert atmosphere

With methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; magnesium sulfate; potassium carbonate; In dichloromethane;
DOI:10.1021/ml200244k

Reference yield:

: 1353557-59-1
(S)-2-((2S,8R,9R)-14-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-8-((((allyloxy)carbonyl)(methyl)amino)methyl)-2,9-dimethyl-12-oxo-3,4,5,6,9,10-hexahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate

: 1353557-43-3
3-[(2S,8R,9R)-8-({[(4-fluorophenyl)methyl](methyl)amino}methyl)-11-[(2S)-1-hydroxypropan-2-yl]-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxaazacyclotetradecin-14-yl]-1-phenylurea

Guidance literature:: Multi-step reaction with 4 steps

1.1: piperidine / N,N-dimethyl-formamide / 0.67 h / 20 °C / Inert atmosphere

1.2: 3 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid / dichloromethane / 1 h / Inert atmosphere

3.1: magnesium sulfate / dichloromethane / 1 h / Inert atmosphere

3.2: 4 h / 20 °C / Inert atmosphere

4.1: methanol; potassium carbonate / 15 h / 20 °C / Inert atmosphere

With piperidine; methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; magnesium sulfate; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml200244k