N-carboxymethyl-succinamic acid 1-(4-tert-butylcarbamoyl-5,5-dimethyl-thiazolidine-3-carbonyl)-2-[2-(2,6-dimethyl-phenoxy)-acetylamino]-3-phenyl-propyl ester

Base Information

Chemical Name:N-carboxymethyl-succinamic acid 1-(4-tert-butylcarbamoyl-5,5-dimethyl-thiazolidine-3-carbonyl)-2-[2-(2,6-dimethyl-phenoxy)-acetylamino]-3-phenyl-propyl ester
CAS No.:343330-17-6
Molecular Formula:C₃₆H₄₈N₄O₉S
Molecular Weight:712.865
Hs Code.:

<i>N</i>-carboxymethyl-succinamic acid 1-(4-<i>tert</i>-butylcarbamoyl-5,5-dimethyl-thiazolidine-3-carbonyl)-2-[2-(2,6-dimethyl-phenoxy)-acetylamino]-3-phenyl-propyl ester

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Chemical Property of N-carboxymethyl-succinamic acid 1-(4-tert-butylcarbamoyl-5,5-dimethyl-thiazolidine-3-carbonyl)-2-[2-(2,6-dimethyl-phenoxy)-acetylamino]-3-phenyl-propyl ester

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Technology Process of N-carboxymethyl-succinamic acid 1-(4-tert-butylcarbamoyl-5,5-dimethyl-thiazolidine-3-carbonyl)-2-[2-(2,6-dimethyl-phenoxy)-acetylamino]-3-phenyl-propyl ester

There total 3 articles about N-carboxymethyl-succinamic acid 1-(4-tert-butylcarbamoyl-5,5-dimethyl-thiazolidine-3-carbonyl)-2-[2-(2,6-dimethyl-phenoxy)-acetylamino]-3-phenyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 189357-33-3
KNI-727

: 343330-17-6
N-carboxymethyl-succinamic acid 1-(4-tert-butylcarbamoyl-5,5-dimethyl-thiazolidine-3-carbonyl)-2-[2-(2,6-dimethyl-phenoxy)-acetylamino]-3-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: dicyclohexylamine / tetrahydrofuran; diethyl ether

2: Et₃N; BOP; HOBt / dimethylformamide

3: TFA

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; triethylamine; N-cyclohexyl-cyclohexanamine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00007-5

Reference yield:

: 343330-15-4
(R)-N-tert-butyl-3-[(2S,3S)-3-(2,6-dimethylphenoxyacetyl)amino-2-succinyloxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

: 343330-17-6
N-carboxymethyl-succinamic acid 1-(4-tert-butylcarbamoyl-5,5-dimethyl-thiazolidine-3-carbonyl)-2-[2-(2,6-dimethyl-phenoxy)-acetylamino]-3-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N; BOP; HOBt / dimethylformamide

2: TFA

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00007-5