(4R)-N-tert-butyl-3-[(2S,3S)-3-{[(2,6-dimethylphenoxy)acetyl]amino}-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Base Information

• Chemical Name: (4R)-N-tert-butyl-3-[(2S,3S)-3-{[(2,6-dimethylphenoxy)acetyl]amino}-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide
• CAS No.: 189357-33-3
• Molecular Formula: C30H41N3O5S
• Molecular Weight: 555.739
• Mol file: 189357-33-3.mol

Synonyms:

Chemical Property of (4R)-N-tert-butyl-3-[(2S,3S)-3-{[(2,6-dimethylphenoxy)acetyl]amino}-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Chemical Property:

• Vapor Pressure: 3.61E-29mmHg at 25°C
• Boiling Point: 829.6°Cat760mmHg
• Flash Point: 455.6°C
• Density: 1.181g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4R)-N-tert-butyl-3-[(2S,3S)-3-{[(2,6-dimethylphenoxy)acetyl]amino}-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

There total 29 articles about (4R)-N-tert-butyl-3-[(2S,3S)-3-{[(2,6-dimethylphenoxy)acetyl]amino}-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(2,6-dimethylphenoxy)acetic acid (13335-71-2) + (R)-N-tert-butyl-3-<(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl>-5,5-dimethyl-1,3-thiazolidine-4-carboxamide (184955-18-8) → KNI-727 (189357-33-3)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

DOI:10.1021/jm980637h

Reference yield:

KNI-1039 (288399-76-8) → 3'-azido-2',3'-deoxythymidine (30516-87-1,399024-19-2) + KNI-727 (189357-33-3)

Guidance literature:

With heat inactivated fetal calf serum; RPMI-1640 culture medium; In dimethyl sulfoxide; at 37 ℃; Kinetics;

DOI:10.1016/S0968-0896(01)00045-1

Reference yield:

KNI-1039 (288399-76-8) → 3'-azido-2',3'-deoxythymidine (30516-87-1,399024-19-2) + KNI-727 (189357-33-3) + 4-(Carboxymethyl-carbamoyl)-butyric acid (1S,2S)-1-((R)-4-tert-butylcarbamoyl-5,5-dimethyl-thiazolidine-3-carbonyl)-2-[2-(2,6-dimethyl-phenoxy)-acetylamino]-3-phenyl-propyl ester

Guidance literature:

With Hank's balanced salt solution; Molt-4 cells; In dimethyl sulfoxide; at 37 ℃; Kinetics;

DOI:10.1016/S0968-0896(01)00045-1

upstream raw materials:

2-(2,6-dimethylphenoxy)acetic acid

(R)-N-tert-butyl-3-<(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl>-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

KNI-1038

KNI-1046

Downstream raw materials:

KNI-1047

KNI-1039

KNI-1046

KNI-1038