2α,3α-epoxy-16α-(1-pyrrolidinyl)-5α-androstan-17-one

Base Information

• Chemical Name: 2α,3α-epoxy-16α-(1-pyrrolidinyl)-5α-androstan-17-one
• CAS No.: 930092-99-2
• Molecular Formula: C₂₃H₃₅NO₂
• Molecular Weight: 357.536
• Mol file: 930092-99-2.mol

Synonyms:

Chemical Property of 2α,3α-epoxy-16α-(1-pyrrolidinyl)-5α-androstan-17-one

Chemical Property:

Purity/Quality:

>95% ^*data from raw suppliers

2α,3α-Epoxy-16α-(1-pyrrolidinyl)-5α-androstan-17-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2α,3α-Epoxy-16α-(1-pyrrolidinyl)-5α-androstan-17-one is a reagent used in the synthesis of rocuronium bromide, an amino steroid that functions as a non-depolarizing neuro muscular blocker.

Technology Process of 2α,3α-epoxy-16α-(1-pyrrolidinyl)-5α-androstan-17-one

There total 2 articles about 2α,3α-epoxy-16α-(1-pyrrolidinyl)-5α-androstan-17-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyrrolidine (123-75-1) → 2α,3α-epoxy-16β-(1-pyrrolidinyl)-5α-androstane-17-one (159325-45-8) + 2α,3α-epoxy-16α-(1-pyrrolidinyl)-5α-androstan-17-one (930092-99-2)

Guidance literature:

2α,3α:16α,17α-diepoxy-17β-acetoxy-5α-androstane; With sodium hydroxide; In methanol; water; at 20 ℃; for 0.5h; Heating / reflux;

pyrrolidine; In methanol; water; at 40 ℃; for 0.25h; Product distribution / selectivity; Heating / reflux;

Reference yield:

pyrrolidine (123-75-1) + 2α,3α-epoxy-5α-androstan-16β-ol-17-one → 2α,3α-epoxy-16β-(1-pyrrolidinyl)-5α-androstane-17-one (159325-45-8) + 2α,3α-epoxy-16α-(1-pyrrolidinyl)-5α-androstan-17-one (930092-99-2)

Guidance literature:

In methanol; water; at 35 - 65 ℃; for 0.5 - 2h; Product distribution / selectivity; Heating / reflux;

Reference yield: 83.0%

2α,3α-epoxy-16α-(1-pyrrolidinyl)-5α-androstan-17-one (930092-99-2) → 2α,3α-epoxy-16β-(1-pyrrolidinyl)-5α-androstane-17-one (159325-45-8)

Guidance literature:

2α,3α-epoxy-16α-(1-pyrrolidinyl)-5α-androstan-17-one; In methanol; at 60 - 65 ℃; for 0.333333 - 0.5h; Heating / reflux;

With water; In methanol; at 65 - 70 ℃; for 0.833333 - 2h; Purification / work up; Heating / reflux;

upstream raw materials:

pyrrolidine

Downstream raw materials:

(2α,3α,5α,16β,17β)-2,3-epoxy-16-(1-pyrrolidinyl)-androstan-17-ol

2α,3α-epoxy-16β-(1-pyrrolidinyl)-5α-androstane-17-one

Refernces