tert-Butyl-((5Z,8Z,11Z,14Z)-5,6-difluoro-icosa-5,8,11,14-tetraenyloxy)-diphenyl-silane

Base Information

Chemical Name:tert-Butyl-((5Z,8Z,11Z,14Z)-5,6-difluoro-icosa-5,8,11,14-tetraenyloxy)-diphenyl-silane
CAS No.:179872-59-4
Molecular Formula:C₃₆H₅₀F₂OSi
Molecular Weight:564.875
Hs Code.:

Synonyms:

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Chemical Property of tert-Butyl-((5Z,8Z,11Z,14Z)-5,6-difluoro-icosa-5,8,11,14-tetraenyloxy)-diphenyl-silane

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Technology Process of tert-Butyl-((5Z,8Z,11Z,14Z)-5,6-difluoro-icosa-5,8,11,14-tetraenyloxy)-diphenyl-silane

There total 9 articles about tert-Butyl-((5Z,8Z,11Z,14Z)-5,6-difluoro-icosa-5,8,11,14-tetraenyloxy)-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 13553-09-8
(3Z,6Z)-1-oxo-dodecadienal

: [(Z)-8-(tert-Butyl-diphenyl-silanyloxy)-3,4-difluoro-oct-3-enyl]-triphenyl-phosphonium; chloride

: 179872-59-4
tert-Butyl-((5Z,8Z,11Z,14Z)-5,6-difluoro-icosa-5,8,11,14-tetraenyloxy)-diphenyl-silane

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; In tetrahydrofuran; -78 deg C, 30 min; 0 deg C, 1 h; 30 min, RT;
DOI:10.1016/0040-4039(96)00976-8

Reference yield:

: 179872-50-5
(E)-7-Benzyloxy-3-hydroxy-2-phenylsulfanyl-hept-2-enoic acid methyl ester

: 179872-59-4
tert-Butyl-((5Z,8Z,11Z,14Z)-5,6-difluoro-icosa-5,8,11,14-tetraenyloxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 10 steps

1: 75 percent / MeDAST / CH₂Cl₂ / 48 h / Ambient temperature

2: 91 percent / (n-Bu)3SnH / AIBN / toluene / Heating

3: 92 percent / H₂ / Pearlman's catalyst / ethyl acetate / 6 h / 760 Torr

4: 96 percent / Et₃N, DMAP / CH₂Cl₂ / Ambient temperature

5: 66 percent / <(CH₃)3Si>2NNa / tetrahydrofuran / 1 h / Ambient temperature

6: 94 percent / DIBAL / hexane; diethyl ether / 1 h

7: 96 percent / 1-bromo-N,N-2-trimethylpropenylamine / CH₂Cl₂ / 0.25 h / 0 °C

8: tetrahydrofuran / 12 h / Ambient temperature

9: 1.) Amberlyst A₂₁, HCl form; 2.) Amberlyst A₂₆, Cl^(1-) / 1.5 h

10: 23 percent / n-BuLi, HMPTA / tetrahydrofuran / -78 deg C, 30 min; 0 deg C, 1 h; 30 min, RT

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; n-butyllithium; amberlyst A₂₁; dimethylaminosulphur trifluoride; 1-bromo-N,N,2-trimethyl-1-propen-1-amine; chloride; hydrogen; tri-n-butyl-tin hydride; sodium hexamethyldisilazane; diisobutylaluminium hydride; triethylamine; Amberlyst A₂₆; palladium dihydroxide; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; diethyl ether; hexane; dichloromethane; ethyl acetate; toluene;
DOI:10.1016/0040-4039(96)00976-8

Reference yield:

: 179872-52-7
7-Benzyloxy-2,3,3-trifluoro-2-phenylsulfanyl-heptanoic acid methyl ester

: 179872-59-4
tert-Butyl-((5Z,8Z,11Z,14Z)-5,6-difluoro-icosa-5,8,11,14-tetraenyloxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 9 steps

1: 91 percent / (n-Bu)3SnH / AIBN / toluene / Heating

2: 92 percent / H₂ / Pearlman's catalyst / ethyl acetate / 6 h / 760 Torr

3: 96 percent / Et₃N, DMAP / CH₂Cl₂ / Ambient temperature

4: 66 percent / <(CH₃)3Si>2NNa / tetrahydrofuran / 1 h / Ambient temperature

5: 94 percent / DIBAL / hexane; diethyl ether / 1 h

6: 96 percent / 1-bromo-N,N-2-trimethylpropenylamine / CH₂Cl₂ / 0.25 h / 0 °C

7: tetrahydrofuran / 12 h / Ambient temperature

8: 1.) Amberlyst A₂₁, HCl form; 2.) Amberlyst A₂₆, Cl^(1-) / 1.5 h

9: 23 percent / n-BuLi, HMPTA / tetrahydrofuran / -78 deg C, 30 min; 0 deg C, 1 h; 30 min, RT

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; n-butyllithium; amberlyst A₂₁; 1-bromo-N,N,2-trimethyl-1-propen-1-amine; chloride; hydrogen; tri-n-butyl-tin hydride; sodium hexamethyldisilazane; diisobutylaluminium hydride; triethylamine; Amberlyst A₂₆; palladium dihydroxide; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; diethyl ether; hexane; dichloromethane; ethyl acetate; toluene;
DOI:10.1016/0040-4039(96)00976-8