7-Benzyloxy-2,3,3-trifluoro-2-phenylsulfanyl-heptanoic acid methyl ester

Base Information

• Chemical Name: 7-Benzyloxy-2,3,3-trifluoro-2-phenylsulfanyl-heptanoic acid methyl ester
• CAS No.: 179872-52-7
• Molecular Formula: C₂₁H₂₃F₃O₃S
• Molecular Weight: 412.473

Synonyms:7-Benzyloxy-2,3,3-trifluoro-2-phenylsulfanyl-heptanoic acid methyl ester

Chemical Property of 7-Benzyloxy-2,3,3-trifluoro-2-phenylsulfanyl-heptanoic acid methyl ester

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Technology Process of 7-Benzyloxy-2,3,3-trifluoro-2-phenylsulfanyl-heptanoic acid methyl ester

There total 3 articles about 7-Benzyloxy-2,3,3-trifluoro-2-phenylsulfanyl-heptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(E)-7-Benzyloxy-3-hydroxy-2-phenylsulfanyl-hept-2-enoic acid methyl ester (179872-50-5) → 7-Benzyloxy-2,3,3-trifluoro-2-phenylsulfanyl-heptanoic acid methyl ester (179872-52-7)

Guidance literature:

With dimethylaminosulphur trifluoride; In dichloromethane; for 48h; Ambient temperature;

DOI:10.1016/0040-4039(96)00976-8

Reference yield:

1-[(3-bromopropoxy)methyl]-benzene (54314-84-0) → 7-Benzyloxy-2,3,3-trifluoro-2-phenylsulfanyl-heptanoic acid methyl ester (179872-52-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / NaH, N-BuLi / tetrahydrofuran

2: 75 percent / MeDAST / CH₂Cl₂ / 48 h / Ambient temperature

With n-butyllithium; dimethylaminosulphur trifluoride; sodium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/0040-4039(96)00976-8

Reference yield:

methyl (E)-3-hydroxy-2-(phenylthio)but-2-enoate (28195-16-6) → 7-Benzyloxy-2,3,3-trifluoro-2-phenylsulfanyl-heptanoic acid methyl ester (179872-52-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / NaH, N-BuLi / tetrahydrofuran

2: 75 percent / MeDAST / CH₂Cl₂ / 48 h / Ambient temperature

With n-butyllithium; dimethylaminosulphur trifluoride; sodium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/0040-4039(96)00976-8

upstream raw materials:

(E)-7-Benzyloxy-3-hydroxy-2-phenylsulfanyl-hept-2-enoic acid methyl ester

1-[(3-bromopropoxy)methyl]-benzene

methyl (E)-3-hydroxy-2-(phenylthio)but-2-enoate

Downstream raw materials:

tert-Butyl-((5Z,8Z,11Z,14Z)-5,6-difluoro-icosa-5,8,11,14-tetraenyloxy)-diphenyl-silane

7-(tert-Butyl-diphenyl-silanyloxy)-2,3,3-trifluoro-heptanoic acid methyl ester

(Z)-7-(tert-Butyl-diphenyl-silanyloxy)-2,3-difluoro-hept-2-en-1-ol

((Z)-7-Bromo-5,6-difluoro-hept-5-enyloxy)-tert-butyl-diphenyl-silane

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