Technology Process of C19H26O3SeSi
There total 4 articles about C19H26O3SeSi which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(R)-5-((S)-2-methyl-2-(trimethylsilyloxy)penta-3,4-dienyl)dihydrofuran-2(3H)-one;
With
tetramethylsilane; lithium hexamethyldisilazane;
In
tetrahydrofuran; toluene;
at -78 ℃;
for 2h;
Inert atmosphere;
Phenylselenyl chloride;
In
tetrahydrofuran; toluene;
at -78 ℃;
for 0.666667h;
Overall yield = 83 %; Overall yield = 2 g; Optical yield = 20 %de;
Inert atmosphere;
DOI:10.1021/ol401285d
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium chloride / dimethyl sulfoxide; water / 5 h / 155 °C
2.1: diisopropylamine; copper(I) bromide / 1,4-dioxane / 6 h / 125 °C
3.1: 2,6-dimethylpyridine / tetrahydrofuran / 0.5 h / 0 - 20 °C
4.1: lithium hexamethyldisilazane; tetramethylsilane / tetrahydrofuran; toluene / 2 h / -78 °C / Inert atmosphere
4.2: 0.67 h / -78 °C / Inert atmosphere
With
2,6-dimethylpyridine; tetramethylsilane; diisopropylamine; lithium chloride; copper(I) bromide; lithium hexamethyldisilazane;
In
tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; toluene;
1.1: |Krapcho Dealkoxycarbonylation;
DOI:10.1021/ol401285d
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: diisopropylamine; copper(I) bromide / 1,4-dioxane / 6 h / 125 °C
2.1: 2,6-dimethylpyridine / tetrahydrofuran / 0.5 h / 0 - 20 °C
3.1: lithium hexamethyldisilazane; tetramethylsilane / tetrahydrofuran; toluene / 2 h / -78 °C / Inert atmosphere
3.2: 0.67 h / -78 °C / Inert atmosphere
With
2,6-dimethylpyridine; tetramethylsilane; diisopropylamine; copper(I) bromide; lithium hexamethyldisilazane;
In
tetrahydrofuran; 1,4-dioxane; toluene;
DOI:10.1021/ol401285d
