Apigenin 7-glucuronide

Base Information

Chemical Name:Apigenin 7-glucuronide
CAS No.:29741-09-1
Deprecated CAS:68759-17-1,956511-44-7,1382137-35-0
Molecular Formula:C₂₁H₁₈O₁₁
Molecular Weight:446.367
Hs Code.:
European Community (EC) Number:803-513-5
UNII:2CQ5KB3CH0
DSSTox Substance ID:DTXSID10183893
Nikkaji Number:J387.923B
Wikidata:Q72443569
Metabolomics Workbench ID:129687
ChEMBL ID:CHEMBL254213
Mol file:29741-09-1.mol

Synonyms:apigenin-7-O-beta-D-glucuronide;apigenin-7-O-glucuronide

Suppliers and Price of Apigenin 7-glucuronide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Apigenin 7-O-glucuronide
5mg
$ 419.00

TRC
Apigenin 7-glucuronide
1mg
$ 160.00

Sigma-Aldrich
Apigenin 7-glucuronide ≥95% (LC/MS-ELSD)
1mg
$ 247.00

Sigma-Aldrich
Apigenin 7-O-glucuronide primary pharmaceutical reference standard
10mg
$ 407.00

Matrix Scientific
Apigenin 7-O-beta-glucuronide 95+%
1g
$ 1647.00

Matrix Scientific
Apigenin 7-O-beta-glucuronide 95+%
250mg
$ 742.00

DC Chemicals
Apigenin 7-O-glucuronide >98%,StandardReferencesGrade
20 mg
$ 280.00

Crysdot
Apigenin 7-glucuronide 95+%
25mg
$ 530.00

Crysdot
Apigenin 7-glucuronide 95+%
10mg
$ 260.00

Crysdot
Apigenin 7-glucuronide 95+%
5mg
$ 160.00

Total 42 raw suppliers

Chemical Property of Apigenin 7-glucuronide

Chemical Property:

Vapor Pressure:4.28E-30mmHg at 25°C
Melting Point:>300℃
Boiling Point:841.8°Cat760mmHg
PKA:2.73±0.70(Predicted)
Flash Point:299°C
PSA：187.12000
Density:1.737g/cm³
LogP:0.14220
Storage Temp.:?20°C
XLogP3:0.2
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:4
Exact Mass:446.08491139
Heavy Atom Count:32
Complexity:746

Purity/Quality:

95%-98% ^*data from raw suppliers

Apigenin 7-O-glucuronide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)OC4C(C(C(C(O4)C(=O)O)O)O)O)O)O
Isomeric SMILES:C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)C(=O)O)O)O)O)O)O
Uses Apigenin 7-Glucuronide is a metabolite of Apigenin, which induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 uM) by inhibiting MAP kinase activity. Also inhibits the proliferation of malignant tumor cells by G2/M arrest and induces morphological differentiation. Apigenin has also been reported to enhance the gap juntion intracellular communication in liver cells.

Technology Process of Apigenin 7-glucuronide

There total 13 articles about Apigenin 7-glucuronide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 29781-25-7,53538-13-9
apigenin 7-O-β-D-glucopyranosiduronic acid methyl ester

apigenin-7-O-β-D-glucuronide: 29741-09-1,56317-11-4
apigenin-7-O-β-D-glucuronide

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h; Reagent/catalyst; Solvent; Temperature;

Reference yield:

: C₁₅H₂₂N₂O₁₈P₂

: 520-36-5
5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

: 29741-09-1,56317-11-4
apigenin-7-glucuronic acid

Guidance literature:: With uridine 5'-diphosphate glucuronosyltransferase-1A₉; In methanol; aq. phosphate buffer; water; at 37 ℃; pH=7; Reagent/catalyst; Enzymatic reaction;
DOI:10.1021/jf304853j

Reference yield:

: 520-36-5
5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

: 1245697-26-0,106864-00-0,14520-48-0,30329-32-9,3545-73-1,5918-40-1
UDP-glucuronic acid

: 29741-09-1,56317-11-4
apigenin-7-glucuronic acid

Guidance literature:: With human UDP-glucuronosyltransferase 1A₉; magnesium chloride; alamethicin; D-Glucaro-1,4-lacton; at 37 ℃; pH=7.4; Kinetics; aq. phosphate buffer; Enzymatic reaction;
DOI:10.1007/s11095-012-0666-z