methyl ((S)-1-(2-([1,1'-biphenyl]-4-ylmethyl)-2-(3-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Base Information

Chemical Name:methyl ((S)-1-(2-([1,1'-biphenyl]-4-ylmethyl)-2-(3-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate
CAS No.:1365541-72-5
Molecular Formula:C₄₄H₅₂N₄O₆
Molecular Weight:732.92
Hs Code.:

methyl ((S)-1-(2-([1,1'-biphenyl]-4-ylmethyl)-2-(3-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Synonyms:

Suppliers and Price of methyl ((S)-1-(2-([1,1'-biphenyl]-4-ylmethyl)-2-(3-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl ((S)-1-(2-([1,1'-biphenyl]-4-ylmethyl)-2-(3-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl ((S)-1-(2-([1,1'-biphenyl]-4-ylmethyl)-2-(3-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

There total 13 articles about methyl ((S)-1-(2-([1,1'-biphenyl]-4-ylmethyl)-2-(3-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₅₆H₈₀N₄O₆Si₂

: 1365541-72-5
methyl ((S)-1-(2-([1,1'-biphenyl]-4-ylmethyl)-2-(3-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 65 ℃; for 5h;
DOI:10.1021/jm201620t

Reference yield:

: 1365541-34-9
(3S,4S)-3-allyl-3-benzyl-4-((tert-butyldimethylsilyl)oxy)-1-((1S,2R)-2-((tert-butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-yl)pyrrolidin-2-one

: 1365541-72-5
methyl ((S)-1-(2-([1,1'-biphenyl]-4-ylmethyl)-2-(3-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 6 h / 20 - 80 °C

2.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; ethanol; water / 2 h / 20 °C

3.1: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 3 h / 0 - 20 °C

4.1: acetic acid / tetrahydrofuran / 0.33 h / 20 °C / Molecular sieve

4.2: 3 h / 35 °C

5.1: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate / 1,2-dimethoxyethane; water / 0.42 h / 140 °C / Microwave irradiation

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 65 °C

With trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); tetrabutyl ammonium fluoride; dihydrogen peroxide; sulfur trioxide pyridine complex; potassium carbonate; acetic acid; triethylamine; sodium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; dimethyl sulfoxide; 5.1: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jm201620t

Reference yield:

: C₂₉H₃₉NO₃Si

: 1365541-72-5
methyl ((S)-1-(2-([1,1'-biphenyl]-4-ylmethyl)-2-(3-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 0 - 25 °C

2.1: tetrahydrofuran / 6 h / 20 - 80 °C

3.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; ethanol; water / 2 h / 20 °C

4.1: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 3 h / 0 - 20 °C

5.1: acetic acid / tetrahydrofuran / 0.33 h / 20 °C / Molecular sieve

5.2: 3 h / 35 °C

6.1: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate / 1,2-dimethoxyethane; water / 0.42 h / 140 °C / Microwave irradiation

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 65 °C

With trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); tetrabutyl ammonium fluoride; dihydrogen peroxide; sulfur trioxide pyridine complex; potassium carbonate; acetic acid; triethylamine; sodium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; dimethyl sulfoxide; 6.1: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jm201620t